A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function

M Govoni; H.D. Lim; D. El-Atmioui; W.M.P.B. Menge; H. Timmerman; R.A. Bakker; R. Leurs; I.J. De Esch

doi:10.1021/jm0504353

A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function

M Govoni
, H.D. Lim
, D. El-Atmioui
, W.M.P.B. Menge
, H. Timmerman
, R.A. Bakker
, R. Leurs
, I.J. De Esch

Chemistry and Pharmaceutical Sciences

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

In an effort to establish the structural requirements for agonism, neutral antagonism, and inverse agonism at the human histamine H

Original language	English
Pages (from-to)	2549-57
Journal	Journal of Medicinal Chemistry
Volume	49
Issue number	8
DOIs	https://doi.org/10.1021/jm0504353
Publication status	Published - 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1021/jm0504353

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Govoni, M., Lim, H. D., El-Atmioui, D., Menge, W. M. P. B., Timmerman, H., Bakker, R. A., Leurs, R., & De Esch, I. J. (2006). A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function. Journal of Medicinal Chemistry, 49(8), 2549-57. https://doi.org/10.1021/jm0504353

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title = "A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function",

abstract = "In an effort to establish the structural requirements for agonism, neutral antagonism, and inverse agonism at the human histamine H",

author = "M Govoni and H.D. Lim and D. El-Atmioui and W.M.P.B. Menge and H. Timmerman and R.A. Bakker and R. Leurs and \{De Esch\}, I.J.",

year = "2006",

doi = "10.1021/jm0504353",

language = "English",

volume = "49",

pages = "2549--57",

journal = "Journal of Medicinal Chemistry",

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publisher = "American Chemical Society",

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Govoni, M, Lim, HD, El-Atmioui, D, Menge, WMPB, Timmerman, H, Bakker, RA, Leurs, R & De Esch, IJ 2006, 'A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function', Journal of Medicinal Chemistry, vol. 49, no. 8, pp. 2549-57. https://doi.org/10.1021/jm0504353

A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function. / Govoni, M; Lim, H.D.; El-Atmioui, D. et al.
In: Journal of Medicinal Chemistry, Vol. 49, No. 8, 2006, p. 2549-57.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function

AU - Govoni, M

AU - Lim, H.D.

AU - El-Atmioui, D.

AU - Menge, W.M.P.B.

AU - Timmerman, H.

AU - Bakker, R.A.

AU - Leurs, R.

AU - De Esch, I.J.

PY - 2006

Y1 - 2006

N2 - In an effort to establish the structural requirements for agonism, neutral antagonism, and inverse agonism at the human histamine H

AB - In an effort to establish the structural requirements for agonism, neutral antagonism, and inverse agonism at the human histamine H

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U2 - 10.1021/jm0504353

DO - 10.1021/jm0504353

M3 - Article

SN - 0022-2623

VL - 49

SP - 2549

EP - 2557

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 8

ER -

A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function

Abstract

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