A combined cellomics and proteomics approach to uncover neuronal pathways to psychiatric disorder

Martina Rosato, Titia Gebuis, Iryna Paliukhovich, Sven Stringer, Patrick F. Sullivan, August B. Smit, Ronald E. van Kesteren

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Abstract

Studying biological mechanisms underlying neuropsychiatric disorders is highly challenging as many risk genes are associated with these disorders. This complexity requires research approaches to reliably dissect the cell biology of the risk genes involved. Here, we describe a combined cellomics–proteomics approach that allows (a) medium-throughput functional screening and unbiased selection of important risk genes, and (b) discovery of common functional pathways and interactome connections of selected risk genes. The overlay of pathway and proteome data from selected genes in a biological context can be used to formulate new testable hypothesis of both the genetics and the biology of the disorders.

Original languageEnglish
Title of host publicationNeuroproteomics
EditorsKa Wan Li
PublisherHumana Press Inc.
Pages199-215
Number of pages17
Edition2nd
ISBN (Electronic)9781493996629
ISBN (Print)9781493996612
DOIs
Publication statusPublished - 2019

Publication series

NameNeuromethods
Volume146
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Fingerprint

Proteomics
Psychiatry
Genes
Inborn Genetic Diseases
Cytology
Genetic Association Studies
Proteome
Cell Biology
Screening
Throughput
Research

Keywords

  • Cellomics
  • High-content screening
  • Proteomics
  • Psychiatric disorders

Cite this

Rosato, M., Gebuis, T., Paliukhovich, I., Stringer, S., Sullivan, P. F., Smit, A. B., & van Kesteren, R. E. (2019). A combined cellomics and proteomics approach to uncover neuronal pathways to psychiatric disorder. In K. W. Li (Ed.), Neuroproteomics (2nd ed., pp. 199-215). (Neuromethods; Vol. 146). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-9662-9_16
Rosato, Martina ; Gebuis, Titia ; Paliukhovich, Iryna ; Stringer, Sven ; Sullivan, Patrick F. ; Smit, August B. ; van Kesteren, Ronald E. / A combined cellomics and proteomics approach to uncover neuronal pathways to psychiatric disorder. Neuroproteomics. editor / Ka Wan Li. 2nd. ed. Humana Press Inc., 2019. pp. 199-215 (Neuromethods).
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Rosato, M, Gebuis, T, Paliukhovich, I, Stringer, S, Sullivan, PF, Smit, AB & van Kesteren, RE 2019, A combined cellomics and proteomics approach to uncover neuronal pathways to psychiatric disorder. in KW Li (ed.), Neuroproteomics. 2nd edn, Neuromethods, vol. 146, Humana Press Inc., pp. 199-215. https://doi.org/10.1007/978-1-4939-9662-9_16

A combined cellomics and proteomics approach to uncover neuronal pathways to psychiatric disorder. / Rosato, Martina; Gebuis, Titia; Paliukhovich, Iryna; Stringer, Sven; Sullivan, Patrick F.; Smit, August B.; van Kesteren, Ronald E.

Neuroproteomics. ed. / Ka Wan Li. 2nd. ed. Humana Press Inc., 2019. p. 199-215 (Neuromethods; Vol. 146).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

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Rosato M, Gebuis T, Paliukhovich I, Stringer S, Sullivan PF, Smit AB et al. A combined cellomics and proteomics approach to uncover neuronal pathways to psychiatric disorder. In Li KW, editor, Neuroproteomics. 2nd ed. Humana Press Inc. 2019. p. 199-215. (Neuromethods). https://doi.org/10.1007/978-1-4939-9662-9_16