A common biological basis of obesity and nicotine addiction

T.E. Thorgeirsson, D.F. Gudbjartsson, P. Sulem, S. Besenbacher, U. Styrkarsdottir, G. Thorleifsson, G.B. Walters, H. Furberg, P.F. Sullivan, J. Marchini, M.I. McCarthy, V. Steinthorsdottir, U. Thorsteinsdottir, K. Stefansson, D. Posthuma

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10
Original languageEnglish
Article numbere308
Pages (from-to)e308
JournalTranslational Psychiatry
Volume3
Early online date1 Oct 2013
DOIs
Publication statusPublished - 2013

Bibliographical note

TAG Consortium; Oxford-GSK Consortium; ENGAGE consortium,

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