A comparative analysis of kinetic models of erythrocyte glycolysis.

F.B. du Preez; R. Conradie; G.P. Penkler; K. Holm; F.L.J. van dooren; J.L. Snoep

doi:10.1016/j.jtbi.2007.10.006

A comparative analysis of kinetic models of erythrocyte glycolysis.

F.B. du Preez, R. Conradie, G.P. Penkler, K. Holm, F.L.J. van dooren, J.L. Snoep

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. © 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	488-496
Journal	Journal of Theoretical Biology
Volume	252
DOIs	https://doi.org/10.1016/j.jtbi.2007.10.006
Publication status	Published - 2008

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title = "A comparative analysis of kinetic models of erythrocyte glycolysis.",

abstract = "Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. {\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

author = "{du Preez}, F.B. and R. Conradie and G.P. Penkler and K. Holm and {van dooren}, F.L.J. and J.L. Snoep",

year = "2008",

doi = "10.1016/j.jtbi.2007.10.006",

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AU - du Preez, F.B.

AU - Conradie, R.

AU - Penkler, G.P.

AU - Holm, K.

AU - van dooren, F.L.J.

AU - Snoep, J.L.

PY - 2008

Y1 - 2008

N2 - Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. © 2007 Elsevier Ltd. All rights reserved.

AB - Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. © 2007 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.jtbi.2007.10.006

DO - 10.1016/j.jtbi.2007.10.006

M3 - Article

SN - 0022-5193

VL - 252

SP - 488

EP - 496

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

ER -

A comparative analysis of kinetic models of erythrocyte glycolysis.

Abstract

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