A comparative analysis of kinetic models of erythrocyte glycolysis.

F.B. du Preez, R. Conradie, G.P. Penkler, K. Holm, F.L.J. van dooren, J.L. Snoep

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. © 2007 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)488-496
JournalJournal of Theoretical Biology
Volume252
DOIs
Publication statusPublished - 2008

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