A conserved function of YidC in the biogenesis of respiratory chain complexes.

M. van der Laan, M.L. Urbanus, C.M. ten Hagen-Jongman ten, N. Nouwen, B. Oudega, N. Harms, A.J.M. Driessen, S. Luirink

    Research output: Contribution to JournalArticleAcademic


    The Escherichia coli inner membrane protein (IMP) YidC is involved in the membrane integration of IMPs both in concert with and independently from the Sec translocase. YidC seems to be dispensable for the assembly of Sec-dependent IMPs, and so far it has been shown to be essential only for the proper Sec-independent integration of some phage coat proteins. Here, we studied the physiological consequences of YidC depletion in an effort to understand the essential function of YidC. The loss of YidC rapidly and specifically induced the Psp stress response, which is accompanied by a reduction of the proton-motive force. This reduction is due to defects in the functional assembly of cytochrome o oxidase and the F
    Original languageEnglish
    Pages (from-to)5801-5806
    Number of pages6
    JournalProceedings of the National Academy of Sciences of the United States of America
    Publication statusPublished - 2003


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