A conserved function of YidC in the biogenesis of respiratory chain complexes.

M. van der Laan, M.L. Urbanus, C.M. ten Hagen-Jongman ten, N. Nouwen, B. Oudega, N. Harms, A.J.M. Driessen, S. Luirink

Research output: Contribution to JournalArticleAcademic

Abstract

The Escherichia coli inner membrane protein (IMP) YidC is involved in the membrane integration of IMPs both in concert with and independently from the Sec translocase. YidC seems to be dispensable for the assembly of Sec-dependent IMPs, and so far it has been shown to be essential only for the proper Sec-independent integration of some phage coat proteins. Here, we studied the physiological consequences of YidC depletion in an effort to understand the essential function of YidC. The loss of YidC rapidly and specifically induced the Psp stress response, which is accompanied by a reduction of the proton-motive force. This reduction is due to defects in the functional assembly of cytochrome o oxidase and the F
Original languageEnglish
Pages (from-to)5801-5806
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
DOIs
Publication statusPublished - 2003

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Inosine Monophosphate
Electron Transport
Proton-Motive Force
Capsid Proteins
Bacteriophages
Membrane Proteins
Escherichia coli
Membranes
cytochrome o oxidase

Cite this

@article{801255ad047444c7bb346e6c475589e9,
title = "A conserved function of YidC in the biogenesis of respiratory chain complexes.",
abstract = "The Escherichia coli inner membrane protein (IMP) YidC is involved in the membrane integration of IMPs both in concert with and independently from the Sec translocase. YidC seems to be dispensable for the assembly of Sec-dependent IMPs, and so far it has been shown to be essential only for the proper Sec-independent integration of some phage coat proteins. Here, we studied the physiological consequences of YidC depletion in an effort to understand the essential function of YidC. The loss of YidC rapidly and specifically induced the Psp stress response, which is accompanied by a reduction of the proton-motive force. This reduction is due to defects in the functional assembly of cytochrome o oxidase and the F",
author = "{van der Laan}, M. and M.L. Urbanus and {ten Hagen-Jongman ten}, C.M. and N. Nouwen and B. Oudega and N. Harms and A.J.M. Driessen and S. Luirink",
year = "2003",
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language = "English",
volume = "100",
pages = "5801--5806",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Acad Sciences",

}

A conserved function of YidC in the biogenesis of respiratory chain complexes. / van der Laan, M.; Urbanus, M.L.; ten Hagen-Jongman ten, C.M.; Nouwen, N.; Oudega, B.; Harms, N.; Driessen, A.J.M.; Luirink, S.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, 2003, p. 5801-5806.

Research output: Contribution to JournalArticleAcademic

TY - JOUR

T1 - A conserved function of YidC in the biogenesis of respiratory chain complexes.

AU - van der Laan, M.

AU - Urbanus, M.L.

AU - ten Hagen-Jongman ten, C.M.

AU - Nouwen, N.

AU - Oudega, B.

AU - Harms, N.

AU - Driessen, A.J.M.

AU - Luirink, S.

PY - 2003

Y1 - 2003

N2 - The Escherichia coli inner membrane protein (IMP) YidC is involved in the membrane integration of IMPs both in concert with and independently from the Sec translocase. YidC seems to be dispensable for the assembly of Sec-dependent IMPs, and so far it has been shown to be essential only for the proper Sec-independent integration of some phage coat proteins. Here, we studied the physiological consequences of YidC depletion in an effort to understand the essential function of YidC. The loss of YidC rapidly and specifically induced the Psp stress response, which is accompanied by a reduction of the proton-motive force. This reduction is due to defects in the functional assembly of cytochrome o oxidase and the F

AB - The Escherichia coli inner membrane protein (IMP) YidC is involved in the membrane integration of IMPs both in concert with and independently from the Sec translocase. YidC seems to be dispensable for the assembly of Sec-dependent IMPs, and so far it has been shown to be essential only for the proper Sec-independent integration of some phage coat proteins. Here, we studied the physiological consequences of YidC depletion in an effort to understand the essential function of YidC. The loss of YidC rapidly and specifically induced the Psp stress response, which is accompanied by a reduction of the proton-motive force. This reduction is due to defects in the functional assembly of cytochrome o oxidase and the F

U2 - 10.1073/pnas.0636761100

DO - 10.1073/pnas.0636761100

M3 - Article

VL - 100

SP - 5801

EP - 5806

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

ER -