A conserved function of YidC in the biogenesis of respiratory chain complexes.

M. van der Laan, M.L. Urbanus, C.M. ten Hagen-Jongman ten, N. Nouwen, B. Oudega, N. Harms, A.J.M. Driessen, S. Luirink

Research output: Contribution to JournalArticleAcademic


The Escherichia coli inner membrane protein (IMP) YidC is involved in the membrane integration of IMPs both in concert with and independently from the Sec translocase. YidC seems to be dispensable for the assembly of Sec-dependent IMPs, and so far it has been shown to be essential only for the proper Sec-independent integration of some phage coat proteins. Here, we studied the physiological consequences of YidC depletion in an effort to understand the essential function of YidC. The loss of YidC rapidly and specifically induced the Psp stress response, which is accompanied by a reduction of the proton-motive force. This reduction is due to defects in the functional assembly of cytochrome o oxidase and the F
Original languageEnglish
Pages (from-to)5801-5806
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Publication statusPublished - 2003


Dive into the research topics of 'A conserved function of YidC in the biogenesis of respiratory chain complexes.'. Together they form a unique fingerprint.

Cite this