A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response

Funding

We are grateful to Yoav Arava, Ofri Levi and Ayala Shiber for their help in designing and analyzing the polysome profiling experiment and for providing necessary materials. We thank Varada Liveanu for helping in the bacterial purification of human RBM42 protein. We thank David Meiri’s Lab for providing us the BioVision, 1006-200 kit used for the Annexin V-FITS experiment. We thank Tamar Lahav for her help in eCLIP data release. We thank Enas Abu-Zhayia, Alma-Sophia Barisaac, and Inna Pigalchock for helping setup the minigene splicing reporter assay. We thank bioRENDER (biorender.com) for assisting in drawing the model and the schematics presented in the figures. Research in the Ayoub lab is supported by grants from the Israel Science Foundation (2511/19), ISF-NSFC fund (# 2511/18), Israel Cancer Association (20200080). B.M.B.-O. is supported by TICC fellowship. F.E.M. is supported by Irwin and Joan Jacob and Clore fellowship. M.N. is supported by the VATAT fellowship for outstanding minority MSc students. YMG research is supported by the Israel Science Foundation (1556/22). R.H is supported by the Neubauer Family foundation. OK research is supported by grants from the Israel Science Foundation (1623/17 and 2167/17). N.A. is supported by the Neubauer Family foundation.