A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder

E.C. Verbeek, I.M.C. Bakker, M.R. Bevova, Z. Bochdanovits, P. Rizzu, D. Sondervan, G. Willemsen, E.J.C. de Geus, J.H. Smit, B.W.J.H. Penninx, D.I. Boomsma, W.J.G. Hoogendijk, P. Heutink

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Abstract

Major depressive disorder (MDD) is a psychiatric disorder that is characterized -amongst others- by persistent depressed mood, loss of interest and pleasure and psychomotor retardation. Environmental circumstances have proven to influence the aetiology of the disease, but MDD also has an estimated 40% heritability, probably with a polygenic background. In 2009, a genome wide association study (GWAS) was performed on the Dutch GAIN-MDD cohort. A non-synonymous coding single nucleotide polymorphism (SNP) rs2522833 in the PCLO gene became only nominally significant after post-hoc analysis with an Australian cohort which used similar ascertainment. The absence of genome-wide significance may be caused by low SNP coverage of genes. To increase SNP coverage to 100% for common variants (m.a.f.>0.1, r
Original languageEnglish
Article numbere37384
Pages (from-to)e37384
JournalPLoS ONE
Volume7
Issue number5
DOIs
Publication statusPublished - 2012

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Verbeek, E. C., Bakker, I. M. C., Bevova, M. R., Bochdanovits, Z., Rizzu, P., Sondervan, D., ... Heutink, P. (2012). A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder. PLoS ONE, 7(5), e37384. [e37384]. https://doi.org/10.1371/journal.pone.0037384