A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder

E.C. Verbeek; I.M.C. Bakker; M.R. Bevova; Z. Bochdanovits; P. Rizzu; D. Sondervan; G. Willemsen; E.J.C. de Geus; J.H. Smit; B.W.J.H. Penninx; D.I. Boomsma; W.J.G. Hoogendijk; P. Heutink

doi:10.1371/journal.pone.0037384

A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder

E.C. Verbeek
, I.M.C. Bakker
, M.R. Bevova
, Z. Bochdanovits
, P. Rizzu
, D. Sondervan
, G. Willemsen
, E.J.C. de Geus
, J.H. Smit
, B.W.J.H. Penninx
, D.I. Boomsma
, W.J.G. Hoogendijk
, P. Heutink

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

189 Downloads (Pure)

Abstract

Major depressive disorder (MDD) is a psychiatric disorder that is characterized -amongst others- by persistent depressed mood, loss of interest and pleasure and psychomotor retardation. Environmental circumstances have proven to influence the aetiology of the disease, but MDD also has an estimated 40% heritability, probably with a polygenic background. In 2009, a genome wide association study (GWAS) was performed on the Dutch GAIN-MDD cohort. A non-synonymous coding single nucleotide polymorphism (SNP) rs2522833 in the PCLO gene became only nominally significant after post-hoc analysis with an Australian cohort which used similar ascertainment. The absence of genome-wide significance may be caused by low SNP coverage of genes. To increase SNP coverage to 100% for common variants (m.a.f.>0.1, r

Original language	English
Article number	e37384
Pages (from-to)	e37384
Journal	PLoS ONE
Volume	7
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0037384
Publication status	Published - 2012

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

10.1371/journal.pone.0037384

295544Final published version, 206 KB

Persistent URL (handle)

Persistent link

Cite this

Verbeek, E. C., Bakker, I. M. C., Bevova, M. R., Bochdanovits, Z., Rizzu, P., Sondervan, D., Willemsen, G., de Geus, E. J. C., Smit, J. H., Penninx, B. W. J. H., Boomsma, D. I., Hoogendijk, W. J. G., & Heutink, P. (2012). A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder. PLoS ONE, 7(5), e37384. Article e37384. https://doi.org/10.1371/journal.pone.0037384

@article{1279d7783b5c43859c8b4a0cfc36b58a,

title = "A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder",

abstract = "Major depressive disorder (MDD) is a psychiatric disorder that is characterized -amongst others- by persistent depressed mood, loss of interest and pleasure and psychomotor retardation. Environmental circumstances have proven to influence the aetiology of the disease, but MDD also has an estimated 40\% heritability, probably with a polygenic background. In 2009, a genome wide association study (GWAS) was performed on the Dutch GAIN-MDD cohort. A non-synonymous coding single nucleotide polymorphism (SNP) rs2522833 in the PCLO gene became only nominally significant after post-hoc analysis with an Australian cohort which used similar ascertainment. The absence of genome-wide significance may be caused by low SNP coverage of genes. To increase SNP coverage to 100\% for common variants (m.a.f.>0.1, r",

author = "E.C. Verbeek and I.M.C. Bakker and M.R. Bevova and Z. Bochdanovits and P. Rizzu and D. Sondervan and G. Willemsen and \{de Geus\}, E.J.C. and J.H. Smit and B.W.J.H. Penninx and D.I. Boomsma and W.J.G. Hoogendijk and P. Heutink",

year = "2012",

doi = "10.1371/journal.pone.0037384",

language = "English",

volume = "7",

pages = "e37384",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "5",

}

TY - JOUR

T1 - A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder

AU - Verbeek, E.C.

AU - Bakker, I.M.C.

AU - Bevova, M.R.

AU - Bochdanovits, Z.

AU - Rizzu, P.

AU - Sondervan, D.

AU - Willemsen, G.

AU - de Geus, E.J.C.

AU - Smit, J.H.

AU - Penninx, B.W.J.H.

AU - Boomsma, D.I.

AU - Hoogendijk, W.J.G.

AU - Heutink, P.

PY - 2012

Y1 - 2012

N2 - Major depressive disorder (MDD) is a psychiatric disorder that is characterized -amongst others- by persistent depressed mood, loss of interest and pleasure and psychomotor retardation. Environmental circumstances have proven to influence the aetiology of the disease, but MDD also has an estimated 40% heritability, probably with a polygenic background. In 2009, a genome wide association study (GWAS) was performed on the Dutch GAIN-MDD cohort. A non-synonymous coding single nucleotide polymorphism (SNP) rs2522833 in the PCLO gene became only nominally significant after post-hoc analysis with an Australian cohort which used similar ascertainment. The absence of genome-wide significance may be caused by low SNP coverage of genes. To increase SNP coverage to 100% for common variants (m.a.f.>0.1, r

AB - Major depressive disorder (MDD) is a psychiatric disorder that is characterized -amongst others- by persistent depressed mood, loss of interest and pleasure and psychomotor retardation. Environmental circumstances have proven to influence the aetiology of the disease, but MDD also has an estimated 40% heritability, probably with a polygenic background. In 2009, a genome wide association study (GWAS) was performed on the Dutch GAIN-MDD cohort. A non-synonymous coding single nucleotide polymorphism (SNP) rs2522833 in the PCLO gene became only nominally significant after post-hoc analysis with an Australian cohort which used similar ascertainment. The absence of genome-wide significance may be caused by low SNP coverage of genes. To increase SNP coverage to 100% for common variants (m.a.f.>0.1, r

U2 - 10.1371/journal.pone.0037384

DO - 10.1371/journal.pone.0037384

M3 - Article

SN - 1932-6203

VL - 7

SP - e37384

JO - PLoS ONE

JF - PLoS ONE

IS - 5

M1 - e37384

ER -

A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder

Abstract

Cohort Studies

Access to Document

Persistent URL (handle)

Fingerprint

Cite this