TY - JOUR
T1 - A first update on mapping the human genetic architecture of COVID-19
AU - COVID-19 Host Genetics Initiative
AU - Hottenga, Jouke Jan
AU - Bartels, Meike
AU - de Geus, Eco J.C.
AU - Nivard, Michel
PY - 2022/8/4
Y1 - 2022/8/4
N2 - The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity...
AB - The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity...
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U2 - 10.1038/s41586-022-04826-7
DO - 10.1038/s41586-022-04826-7
M3 - Article
C2 - 35922517
AN - SCOPUS:85135433188
SN - 0028-0836
VL - 608
SP - E1-E10
JO - Nature
JF - Nature
IS - 7921
ER -