A first update on mapping the human genetic architecture of COVID-19

COVID-19 Host Genetics Initiative, Jouke Jan Hottenga, Meike Bartels, Eco J.C. de Geus, Michel Nivard

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity...
Original languageEnglish
Pages (from-to)E1-E10
Number of pages10
JournalNature
Volume608
Issue number7921
Early online date3 Aug 2022
DOIs
Publication statusPublished - 4 Aug 2022

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