A genetic analysis of ambulatory cardiorespiratory coupling

H.M. Kupper; G. Willemsen; D. Posthuma; D. de Boer; D.I. Boomsma; E.J.C. de Geus

doi:10.1111/j.1469-8986.2005.00276.x

A genetic analysis of ambulatory cardiorespiratory coupling

H.M. Kupper, G. Willemsen, D. Posthuma, D. de Boer, D.I. Boomsma, E.J.C. de Geus

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

222 Downloads (Pure)

Abstract

This study assessed the heritability of ambulatory heart period, respiratory sinus arrhythmia (RSA), and respiration rate and tested the hypothesis that the well-established correlation between these variables is determined by common genetic factors. In 780 healthy twins and siblings, 24-h ambulatory recordings of ECG and thorax impedance were made. Genetic analyses showed considerable heritability for heart period (37%-48%), RSA (40%-55%), and respiration rate (27%-81%) at all daily periods. Significant genetic correlations were found throughout. Common genes explained large portions of the covariance between heart period and RSA and between respiration rate and RSA. During the afternoon and night, the covariance between respiration rate and RSA was completely determined by common genes. This overlap in genes can be exploited to increase the power of linkage studies to detect genetic variation influencing cardiovascular disease risk. Copyright © 2005 Society for Psychophysiological Research.

Original language	English
Pages (from-to)	202-212
Journal	Psychophysiology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1111/j.1469-8986.2005.00276.x
Publication status	Published - 2005

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1469-8986.2005.00276.x

Kupper Psychophysiology 42(2) 2005 uFinal published version, 1.8 MB

http://www.tweelingenregister.org/nederlands/verslaggeving/NTR_publicaties_2005/Kupper_Psychophysiology_2005.pdf

Persistent URL (handle)

Persistent link

Cite this

@article{9a09bc512e8d4c849eabc9455a9529c1,

title = "A genetic analysis of ambulatory cardiorespiratory coupling",

abstract = "This study assessed the heritability of ambulatory heart period, respiratory sinus arrhythmia (RSA), and respiration rate and tested the hypothesis that the well-established correlation between these variables is determined by common genetic factors. In 780 healthy twins and siblings, 24-h ambulatory recordings of ECG and thorax impedance were made. Genetic analyses showed considerable heritability for heart period (37%-48%), RSA (40%-55%), and respiration rate (27%-81%) at all daily periods. Significant genetic correlations were found throughout. Common genes explained large portions of the covariance between heart period and RSA and between respiration rate and RSA. During the afternoon and night, the covariance between respiration rate and RSA was completely determined by common genes. This overlap in genes can be exploited to increase the power of linkage studies to detect genetic variation influencing cardiovascular disease risk. Copyright {\textcopyright} 2005 Society for Psychophysiological Research.",

author = "H.M. Kupper and G. Willemsen and D. Posthuma and {de Boer}, D. and D.I. Boomsma and {de Geus}, E.J.C.",

year = "2005",

doi = "10.1111/j.1469-8986.2005.00276.x",

language = "English",

volume = "42",

pages = "202--212",

journal = "Psychophysiology",

issn = "0048-5772",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - A genetic analysis of ambulatory cardiorespiratory coupling

AU - Kupper, H.M.

AU - Willemsen, G.

AU - Posthuma, D.

AU - de Boer, D.

AU - Boomsma, D.I.

AU - de Geus, E.J.C.

PY - 2005

Y1 - 2005

N2 - This study assessed the heritability of ambulatory heart period, respiratory sinus arrhythmia (RSA), and respiration rate and tested the hypothesis that the well-established correlation between these variables is determined by common genetic factors. In 780 healthy twins and siblings, 24-h ambulatory recordings of ECG and thorax impedance were made. Genetic analyses showed considerable heritability for heart period (37%-48%), RSA (40%-55%), and respiration rate (27%-81%) at all daily periods. Significant genetic correlations were found throughout. Common genes explained large portions of the covariance between heart period and RSA and between respiration rate and RSA. During the afternoon and night, the covariance between respiration rate and RSA was completely determined by common genes. This overlap in genes can be exploited to increase the power of linkage studies to detect genetic variation influencing cardiovascular disease risk. Copyright © 2005 Society for Psychophysiological Research.

AB - This study assessed the heritability of ambulatory heart period, respiratory sinus arrhythmia (RSA), and respiration rate and tested the hypothesis that the well-established correlation between these variables is determined by common genetic factors. In 780 healthy twins and siblings, 24-h ambulatory recordings of ECG and thorax impedance were made. Genetic analyses showed considerable heritability for heart period (37%-48%), RSA (40%-55%), and respiration rate (27%-81%) at all daily periods. Significant genetic correlations were found throughout. Common genes explained large portions of the covariance between heart period and RSA and between respiration rate and RSA. During the afternoon and night, the covariance between respiration rate and RSA was completely determined by common genes. This overlap in genes can be exploited to increase the power of linkage studies to detect genetic variation influencing cardiovascular disease risk. Copyright © 2005 Society for Psychophysiological Research.

U2 - 10.1111/j.1469-8986.2005.00276.x

DO - 10.1111/j.1469-8986.2005.00276.x

M3 - Article

SN - 0048-5772

VL - 42

SP - 202

EP - 212

JO - Psychophysiology

JF - Psychophysiology

IS - 2

ER -

A genetic analysis of ambulatory cardiorespiratory coupling

Abstract

Cohort Studies

UN SDGs

Access to Document

Persistent URL (handle)

Fingerprint

Cite this