A genome-wide association meta-analysis identifies new childhood obesity loci

J.P. Bradfield; H.R. Taal; N.J. Timpson; A. Scherag; C. Lecoeur; N.M. Warrington; E. Hypponen; C. Holst; B. Valcarcel; E. Thiering; R.M. Salem; F.R. Schumacher; D.L. Cousminer; P.M.A. Sleiman; J. Zhao; R.I. Berkowitz; K.S. Vimaleswaran; I. Jarick; C.E. Pennell; D.M. Evans; B. St Pourcain; D.J. Berry; D.O. Mook-Kanamori; A. Hofman; F. Rivadeneira; A.G. Uitterlinden; C.M. van Duijn; R.J.P. van der Valk; J.C. de Jongste; D.S. Postma; D.I. Boomsma; W.J. Gauderman; M.T. Hassanein; C.M. Lindgren; R. Mägi; C.A.G. Boreham; C.E. Neville; L.A. Moreno; P. Elliott; A. Pouta; A.-L. Hartikainen; M. Li; O. Raitakari; T. Lehtimäki; J.G. Eriksson; A. Palotie; J. Dallongeville; S. Das; P. Deloukas; G. McMahon; S.M. Ring; J.P. Kemp; J.L. Buxton; A.I.F. Blakemore; M. Bustamante; M. Guxens; J.N. Hirschhorn; M.W. Gillman; E. Kreiner-Møller; H. Bisgaard; F.D. Gilliland; J. Heinrich; E. Wheeler; I. Barroso; S. O'Rahilly; A. Meirhaeghe; T.I.A. Sørensen; C. Power; L.J. Palmer; A. Hinney; E. Widen; I.S. Farooqi; M.I. McCarthy; P. Froguel; D. Meyre; J. Hebebrand; M.J. Järvelin; V.W.V. Jaddoe; G.D. Smith; H. Hakonarson; S.F.A. Grant

doi:10.1038/ng.2247

A genome-wide association meta-analysis identifies new childhood obesity loci

J.P. Bradfield, H.R. Taal, N.J. Timpson, A. Scherag, C. Lecoeur, N.M. Warrington, E. Hypponen, C. Holst, B. Valcarcel, E. Thiering, R.M. Salem, F.R. Schumacher, D.L. Cousminer, P.M.A. Sleiman, J. Zhao, R.I. Berkowitz, K.S. Vimaleswaran, I. Jarick, C.E. Pennell, D.M. EvansB. St Pourcain, D.J. Berry, D.O. Mook-Kanamori, A. Hofman, F. Rivadeneira, A.G. Uitterlinden, C.M. van Duijn, R.J.P. van der Valk, J.C. de Jongste, D.S. Postma, D.I. Boomsma, W.J. Gauderman, M.T. Hassanein, C.M. Lindgren, R. Mägi, C.A.G. Boreham, C.E. Neville, L.A. Moreno, P. Elliott, A. Pouta, A.-L. Hartikainen, M. Li, O. Raitakari, T. Lehtimäki, J.G. Eriksson, A. Palotie, J. Dallongeville, S. Das, P. Deloukas, G. McMahon, S.M. Ring, J.P. Kemp, J.L. Buxton, A.I.F. Blakemore, M. Bustamante, M. Guxens, J.N. Hirschhorn, M.W. Gillman, E. Kreiner-Møller, H. Bisgaard, F.D. Gilliland, J. Heinrich, E. Wheeler, I. Barroso, S. O'Rahilly, A. Meirhaeghe, T.I.A. Sørensen, C. Power, L.J. Palmer, A. Hinney, E. Widen, I.S. Farooqi, M.I. McCarthy, P. Froguel, D. Meyre, J. Hebebrand, M.J. Järvelin, V.W.V. Jaddoe, G.D. Smith, H. Hakonarson, S.F.A. Grant

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10

Original language	English
Pages (from-to)	526-532
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2247
Publication status	Published - 2012

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Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ng.2247

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Bradfield, J. P., Taal, H. R., Timpson, N. J., Scherag, A., Lecoeur, C., Warrington, N. M., Hypponen, E., Holst, C., Valcarcel, B., Thiering, E., Salem, R. M., Schumacher, F. R., Cousminer, D. L., Sleiman, P. M. A., Zhao, J., Berkowitz, R. I., Vimaleswaran, K. S., Jarick, I., Pennell, C. E., ... Grant, S. F. A. (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44(5), 526-532. https://doi.org/10.1038/ng.2247

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title = "A genome-wide association meta-analysis identifies new childhood obesity loci",

abstract = "Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10",

author = "J.P. Bradfield and H.R. Taal and N.J. Timpson and A. Scherag and C. Lecoeur and N.M. Warrington and E. Hypponen and C. Holst and B. Valcarcel and E. Thiering and R.M. Salem and F.R. Schumacher and D.L. Cousminer and P.M.A. Sleiman and J. Zhao and R.I. Berkowitz and K.S. Vimaleswaran and I. Jarick and C.E. Pennell and D.M. Evans and {St Pourcain}, B. and D.J. Berry and D.O. Mook-Kanamori and A. Hofman and F. Rivadeneira and A.G. Uitterlinden and {van Duijn}, C.M. and {van der Valk}, R.J.P. and {de Jongste}, J.C. and D.S. Postma and D.I. Boomsma and W.J. Gauderman and M.T. Hassanein and C.M. Lindgren and R. M{\"a}gi and C.A.G. Boreham and C.E. Neville and L.A. Moreno and P. Elliott and A. Pouta and A.-L. Hartikainen and M. Li and O. Raitakari and T. Lehtim{\"a}ki and J.G. Eriksson and A. Palotie and J. Dallongeville and S. Das and P. Deloukas and G. McMahon and S.M. Ring and J.P. Kemp and J.L. Buxton and A.I.F. Blakemore and M. Bustamante and M. Guxens and J.N. Hirschhorn and M.W. Gillman and E. Kreiner-M{\o}ller and H. Bisgaard and F.D. Gilliland and J. Heinrich and E. Wheeler and I. Barroso and S. O'Rahilly and A. Meirhaeghe and T.I.A. S{\o}rensen and C. Power and L.J. Palmer and A. Hinney and E. Widen and I.S. Farooqi and M.I. McCarthy and P. Froguel and D. Meyre and J. Hebebrand and M.J. J{\"a}rvelin and V.W.V. Jaddoe and G.D. Smith and H. Hakonarson and S.F.A. Grant",

year = "2012",

doi = "10.1038/ng.2247",

language = "English",

volume = "44",

pages = "526--532",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "5",

}

Bradfield, JP, Taal, HR, Timpson, NJ, Scherag, A, Lecoeur, C, Warrington, NM, Hypponen, E, Holst, C, Valcarcel, B, Thiering, E, Salem, RM, Schumacher, FR, Cousminer, DL, Sleiman, PMA, Zhao, J, Berkowitz, RI, Vimaleswaran, KS, Jarick, I, Pennell, CE, Evans, DM, St Pourcain, B, Berry, DJ, Mook-Kanamori, DO, Hofman, A, Rivadeneira, F, Uitterlinden, AG, van Duijn, CM, van der Valk, RJP, de Jongste, JC, Postma, DS, Boomsma, DI, Gauderman, WJ, Hassanein, MT, Lindgren, CM, Mägi, R, Boreham, CAG, Neville, CE, Moreno, LA, Elliott, P, Pouta, A, Hartikainen, A-L, Li, M, Raitakari, O, Lehtimäki, T, Eriksson, JG, Palotie, A, Dallongeville, J, Das, S, Deloukas, P, McMahon, G, Ring, SM, Kemp, JP, Buxton, JL, Blakemore, AIF, Bustamante, M, Guxens, M, Hirschhorn, JN, Gillman, MW, Kreiner-Møller, E, Bisgaard, H, Gilliland, FD, Heinrich, J, Wheeler, E, Barroso, I, O'Rahilly, S, Meirhaeghe, A, Sørensen, TIA, Power, C, Palmer, LJ, Hinney, A, Widen, E, Farooqi, IS, McCarthy, MI, Froguel, P, Meyre, D, Hebebrand, J, Järvelin, MJ, Jaddoe, VWV, Smith, GD, Hakonarson, H & Grant, SFA 2012, 'A genome-wide association meta-analysis identifies new childhood obesity loci', Nature Genetics, vol. 44, no. 5, pp. 526-532. https://doi.org/10.1038/ng.2247

TY - JOUR

T1 - A genome-wide association meta-analysis identifies new childhood obesity loci

AU - Bradfield, J.P.

AU - Taal, H.R.

AU - Timpson, N.J.

AU - Scherag, A.

AU - Lecoeur, C.

AU - Warrington, N.M.

AU - Hypponen, E.

AU - Holst, C.

AU - Valcarcel, B.

AU - Thiering, E.

AU - Salem, R.M.

AU - Schumacher, F.R.

AU - Cousminer, D.L.

AU - Sleiman, P.M.A.

AU - Zhao, J.

AU - Berkowitz, R.I.

AU - Vimaleswaran, K.S.

AU - Jarick, I.

AU - Pennell, C.E.

AU - Evans, D.M.

AU - St Pourcain, B.

AU - Berry, D.J.

AU - Mook-Kanamori, D.O.

AU - Hofman, A.

AU - Rivadeneira, F.

AU - Uitterlinden, A.G.

AU - van Duijn, C.M.

AU - van der Valk, R.J.P.

AU - de Jongste, J.C.

AU - Postma, D.S.

AU - Boomsma, D.I.

AU - Gauderman, W.J.

AU - Hassanein, M.T.

AU - Lindgren, C.M.

AU - Mägi, R.

AU - Boreham, C.A.G.

AU - Neville, C.E.

AU - Moreno, L.A.

AU - Elliott, P.

AU - Pouta, A.

AU - Hartikainen, A.-L.

AU - Li, M.

AU - Raitakari, O.

AU - Lehtimäki, T.

AU - Eriksson, J.G.

AU - Palotie, A.

AU - Dallongeville, J.

AU - Das, S.

AU - Deloukas, P.

AU - McMahon, G.

AU - Ring, S.M.

AU - Kemp, J.P.

AU - Buxton, J.L.

AU - Blakemore, A.I.F.

AU - Bustamante, M.

AU - Guxens, M.

AU - Hirschhorn, J.N.

AU - Gillman, M.W.

AU - Kreiner-Møller, E.

AU - Bisgaard, H.

AU - Gilliland, F.D.

AU - Heinrich, J.

AU - Wheeler, E.

AU - Barroso, I.

AU - O'Rahilly, S.

AU - Meirhaeghe, A.

AU - Sørensen, T.I.A.

AU - Power, C.

AU - Palmer, L.J.

AU - Hinney, A.

AU - Widen, E.

AU - Farooqi, I.S.

AU - McCarthy, M.I.

AU - Froguel, P.

AU - Meyre, D.

AU - Hebebrand, J.

AU - Järvelin, M.J.

AU - Jaddoe, V.W.V.

AU - Smith, G.D.

AU - Hakonarson, H.

AU - Grant, S.F.A.

PY - 2012

Y1 - 2012

N2 - Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10

AB - Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10

U2 - 10.1038/ng.2247

DO - 10.1038/ng.2247

M3 - Article

SN - 1061-4036

VL - 44

SP - 526

EP - 532

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

A genome-wide association meta-analysis identifies new childhood obesity loci

Abstract

Cohort Studies

UN SDGs

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