A genome-wide association meta-analysis identifies new childhood obesity loci

J.P. Bradfield; H.R. Taal; N.J. Timpson; A. Scherag; C. Lecoeur; N.M. Warrington; E. Hypponen; C. Holst; B. Valcarcel; E. Thiering; R.M. Salem; F.R. Schumacher; D.L. Cousminer; P.M.A. Sleiman; J. Zhao; R.I. Berkowitz; K.S. Vimaleswaran; I. Jarick; C.E. Pennell; D.M. Evans; B. St Pourcain; D.J. Berry; D.O. Mook-Kanamori; A. Hofman; F. Rivadeneira; A.G. Uitterlinden; C.M. van Duijn; R.J.P. van der Valk; J.C. de Jongste; D.S. Postma; D.I. Boomsma; W.J. Gauderman; M.T. Hassanein; C.M. Lindgren; R. Mägi; C.A.G. Boreham; C.E. Neville; L.A. Moreno; P. Elliott; A. Pouta; A.-L. Hartikainen; M. Li; O. Raitakari; T. Lehtimäki; J.G. Eriksson; A. Palotie; J. Dallongeville; S. Das; P. Deloukas; G. McMahon; S.M. Ring; J.P. Kemp; J.L. Buxton; A.I.F. Blakemore; M. Bustamante; M. Guxens; J.N. Hirschhorn; M.W. Gillman; E. Kreiner-Møller; H. Bisgaard; F.D. Gilliland; J. Heinrich; E. Wheeler; I. Barroso; S. O'Rahilly; A. Meirhaeghe; T.I.A. Sørensen; C. Power; L.J. Palmer; A. Hinney; E. Widen; I.S. Farooqi; M.I. McCarthy; P. Froguel; D. Meyre; J. Hebebrand; M.J. Järvelin; V.W.V. Jaddoe; G.D. Smith; H. Hakonarson; S.F.A. Grant

doi:10.1038/ng.2247

A genome-wide association meta-analysis identifies new childhood obesity loci

J.P. Bradfield
, H.R. Taal
, N.J. Timpson
, A. Scherag
, C. Lecoeur
, N.M. Warrington
, E. Hypponen
, C. Holst
, B. Valcarcel
, E. Thiering
, R.M. Salem
, F.R. Schumacher
, D.L. Cousminer
, P.M.A. Sleiman
, J. Zhao
, R.I. Berkowitz
, K.S. Vimaleswaran
, I. Jarick
, C.E. Pennell
, D.M. Evans

B. St Pourcain, D.J. Berry, D.O. Mook-Kanamori, A. Hofman, F. Rivadeneira, A.G. Uitterlinden, C.M. van Duijn, R.J.P. van der Valk, J.C. de Jongste, D.S. Postma, D.I. Boomsma, W.J. Gauderman, M.T. Hassanein, C.M. Lindgren, R. Mägi, C.A.G. Boreham, C.E. Neville, L.A. Moreno, P. Elliott, A. Pouta, A.-L. Hartikainen, M. Li, O. Raitakari, T. Lehtimäki, J.G. Eriksson, A. Palotie, J. Dallongeville, S. Das, P. Deloukas, G. McMahon, S.M. Ring, J.P. Kemp, J.L. Buxton, A.I.F. Blakemore, M. Bustamante, M. Guxens, J.N. Hirschhorn, M.W. Gillman, E. Kreiner-Møller, H. Bisgaard, F.D. Gilliland, J. Heinrich, E. Wheeler, I. Barroso, S. O'Rahilly, A. Meirhaeghe, T.I.A. Sørensen, C. Power, L.J. Palmer, A. Hinney, E. Widen, I.S. Farooqi, M.I. McCarthy, P. Froguel, D. Meyre, J. Hebebrand, M.J. Järvelin, V.W.V. Jaddoe, G.D. Smith, H. Hakonarson, S.F.A. Grant

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10

Original language	English
Pages (from-to)	526-532
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2247
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cohort Studies

Netherlands Twin Register (NTR)

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10.1038/ng.2247

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Bradfield, J. P., Taal, H. R., Timpson, N. J., Scherag, A., Lecoeur, C., Warrington, N. M., Hypponen, E., Holst, C., Valcarcel, B., Thiering, E., Salem, R. M., Schumacher, F. R., Cousminer, D. L., Sleiman, P. M. A., Zhao, J., Berkowitz, R. I., Vimaleswaran, K. S., Jarick, I., Pennell, C. E., ... Grant, S. F. A. (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44(5), 526-532. https://doi.org/10.1038/ng.2247

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abstract = "Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10",

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year = "2012",

doi = "10.1038/ng.2247",

language = "English",

volume = "44",

pages = "526--532",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "5",

}

Bradfield, JP, Taal, HR, Timpson, NJ, Scherag, A, Lecoeur, C, Warrington, NM, Hypponen, E, Holst, C, Valcarcel, B, Thiering, E, Salem, RM, Schumacher, FR, Cousminer, DL, Sleiman, PMA, Zhao, J, Berkowitz, RI, Vimaleswaran, KS, Jarick, I, Pennell, CE, Evans, DM, St Pourcain, B, Berry, DJ, Mook-Kanamori, DO, Hofman, A, Rivadeneira, F, Uitterlinden, AG, van Duijn, CM, van der Valk, RJP, de Jongste, JC, Postma, DS, Boomsma, DI, Gauderman, WJ, Hassanein, MT, Lindgren, CM, Mägi, R, Boreham, CAG, Neville, CE, Moreno, LA, Elliott, P, Pouta, A, Hartikainen, A-L, Li, M, Raitakari, O, Lehtimäki, T, Eriksson, JG, Palotie, A, Dallongeville, J, Das, S, Deloukas, P, McMahon, G, Ring, SM, Kemp, JP, Buxton, JL, Blakemore, AIF, Bustamante, M, Guxens, M, Hirschhorn, JN, Gillman, MW, Kreiner-Møller, E, Bisgaard, H, Gilliland, FD, Heinrich, J, Wheeler, E, Barroso, I, O'Rahilly, S, Meirhaeghe, A, Sørensen, TIA, Power, C, Palmer, LJ, Hinney, A, Widen, E, Farooqi, IS, McCarthy, MI, Froguel, P, Meyre, D, Hebebrand, J, Järvelin, MJ, Jaddoe, VWV, Smith, GD, Hakonarson, H & Grant, SFA 2012, 'A genome-wide association meta-analysis identifies new childhood obesity loci', Nature Genetics, vol. 44, no. 5, pp. 526-532. https://doi.org/10.1038/ng.2247

TY - JOUR

T1 - A genome-wide association meta-analysis identifies new childhood obesity loci

AU - Bradfield, J.P.

AU - Taal, H.R.

AU - Timpson, N.J.

AU - Scherag, A.

AU - Lecoeur, C.

AU - Warrington, N.M.

AU - Hypponen, E.

AU - Holst, C.

AU - Valcarcel, B.

AU - Thiering, E.

AU - Salem, R.M.

AU - Schumacher, F.R.

AU - Cousminer, D.L.

AU - Sleiman, P.M.A.

AU - Zhao, J.

AU - Berkowitz, R.I.

AU - Vimaleswaran, K.S.

AU - Jarick, I.

AU - Pennell, C.E.

AU - Evans, D.M.

AU - St Pourcain, B.

AU - Berry, D.J.

AU - Mook-Kanamori, D.O.

AU - Hofman, A.

AU - Rivadeneira, F.

AU - Uitterlinden, A.G.

AU - van Duijn, C.M.

AU - van der Valk, R.J.P.

AU - de Jongste, J.C.

AU - Postma, D.S.

AU - Boomsma, D.I.

AU - Gauderman, W.J.

AU - Hassanein, M.T.

AU - Lindgren, C.M.

AU - Mägi, R.

AU - Boreham, C.A.G.

AU - Neville, C.E.

AU - Moreno, L.A.

AU - Elliott, P.

AU - Pouta, A.

AU - Hartikainen, A.-L.

AU - Li, M.

AU - Raitakari, O.

AU - Lehtimäki, T.

AU - Eriksson, J.G.

AU - Palotie, A.

AU - Dallongeville, J.

AU - Das, S.

AU - Deloukas, P.

AU - McMahon, G.

AU - Ring, S.M.

AU - Kemp, J.P.

AU - Buxton, J.L.

AU - Blakemore, A.I.F.

AU - Bustamante, M.

AU - Guxens, M.

AU - Hirschhorn, J.N.

AU - Gillman, M.W.

AU - Kreiner-Møller, E.

AU - Bisgaard, H.

AU - Gilliland, F.D.

AU - Heinrich, J.

AU - Wheeler, E.

AU - Barroso, I.

AU - O'Rahilly, S.

AU - Meirhaeghe, A.

AU - Sørensen, T.I.A.

AU - Power, C.

AU - Palmer, L.J.

AU - Hinney, A.

AU - Widen, E.

AU - Farooqi, I.S.

AU - McCarthy, M.I.

AU - Froguel, P.

AU - Meyre, D.

AU - Hebebrand, J.

AU - Järvelin, M.J.

AU - Jaddoe, V.W.V.

AU - Smith, G.D.

AU - Hakonarson, H.

AU - Grant, S.F.A.

PY - 2012

Y1 - 2012

N2 - Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10

AB - Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10

U2 - 10.1038/ng.2247

DO - 10.1038/ng.2247

M3 - Article

SN - 1061-4036

VL - 44

SP - 526

EP - 532

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

A genome-wide association meta-analysis identifies new childhood obesity loci

Abstract

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