A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

N.D. Palmer, C.W. McDonough, P.J. Hicks, B.H. Roh, M.R. Wing, S. Sandy An, J.M. Hester, J.N. Cooke, M.A. Bostrom, M.E. Rudock, M.E. Talbert, J.P. Lewis, J.J. Hottenga, E.J.C. de Geus, G. Willemsen, D.I. Boomsma, A. Ferrara, L. Lu, J.T. Ziegler, M.M. SaleJ. Divers, D. Shriner, A. Adeyemo, C.N. Rotimi, M.C.Y. Ng, C.D. Langefeld, B.I. Freedman, D.W. Bowden, D. Posthuma, B.W.J.H. Penninx, R. Sladek

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Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10
Original languageEnglish
Article numbere29202
Pages (from-to)e29202
JournalPLoS ONE
Volume7
Issue number1
DOIs
Publication statusPublished - 2012

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Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., Sandy An, S., ... Sladek, R. (2012). A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans. PLoS ONE, 7(1), e29202. [e29202]. https://doi.org/10.1371/journal.pone.0029202