A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

N.D. Palmer; C.W. McDonough; P.J. Hicks; B.H. Roh; M.R. Wing; S. Sandy An; J.M. Hester; J.N. Cooke; M.A. Bostrom; M.E. Rudock; M.E. Talbert; J.P. Lewis; J.J. Hottenga; E.J.C. de Geus; G. Willemsen; D.I. Boomsma; A. Ferrara; L. Lu; J.T. Ziegler; M.M. Sale; J. Divers; D. Shriner; A. Adeyemo; C.N. Rotimi; M.C.Y. Ng; C.D. Langefeld; B.I. Freedman; D.W. Bowden; D. Posthuma; B.W.J.H. Penninx; R. Sladek

doi:10.1371/journal.pone.0029202

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

N.D. Palmer
, C.W. McDonough
, P.J. Hicks
, B.H. Roh
, M.R. Wing
, S. Sandy An
, J.M. Hester
, J.N. Cooke
, M.A. Bostrom
, M.E. Rudock
, M.E. Talbert
, J.P. Lewis
, J.J. Hottenga
, E.J.C. de Geus
, G. Willemsen
, D.I. Boomsma
, A. Ferrara
, L. Lu
, J.T. Ziegler
, M.M. Sale

J. Divers, D. Shriner, A. Adeyemo, C.N. Rotimi, M.C.Y. Ng, C.D. Langefeld, B.I. Freedman, D.W. Bowden, D. Posthuma, B.W.J.H. Penninx, R. Sladek

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Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10

Original language	English
Article number	e29202
Pages (from-to)	e29202
Journal	PLoS ONE
Volume	7
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0029202
Publication status	Published - 2012

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cohort Studies

Netherlands Twin Register (NTR)

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Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., Sandy An, S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., Boomsma, D. I., Ferrara, A., Lu, L., Ziegler, J. T., ... Sladek, R. (2012). A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans. PLoS ONE, 7(1), e29202. Article e29202. https://doi.org/10.1371/journal.pone.0029202

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title = "A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans",

abstract = "African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10",

author = "N.D. Palmer and C.W. McDonough and P.J. Hicks and B.H. Roh and M.R. Wing and \{Sandy An\}, S. and J.M. Hester and J.N. Cooke and M.A. Bostrom and M.E. Rudock and M.E. Talbert and J.P. Lewis and J.J. Hottenga and \{de Geus\}, E.J.C. and G. Willemsen and D.I. Boomsma and A. Ferrara and L. Lu and J.T. Ziegler and M.M. Sale and J. Divers and D. Shriner and A. Adeyemo and C.N. Rotimi and M.C.Y. Ng and C.D. Langefeld and B.I. Freedman and D.W. Bowden and D. Posthuma and B.W.J.H. Penninx and R. Sladek",

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Palmer, ND, McDonough, CW, Hicks, PJ, Roh, BH, Wing, MR, Sandy An, S, Hester, JM, Cooke, JN, Bostrom, MA, Rudock, ME, Talbert, ME, Lewis, JP, Hottenga, JJ, de Geus, EJC, Willemsen, G, Boomsma, DI, Ferrara, A, Lu, L, Ziegler, JT, Sale, MM, Divers, J, Shriner, D, Adeyemo, A, Rotimi, CN, Ng, MCY, Langefeld, CD, Freedman, BI, Bowden, DW, Posthuma, D, Penninx, BWJH & Sladek, R 2012, 'A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans', PLoS ONE, vol. 7, no. 1, e29202, pp. e29202. https://doi.org/10.1371/journal.pone.0029202

TY - JOUR

T1 - A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

AU - Palmer, N.D.

AU - McDonough, C.W.

AU - Hicks, P.J.

AU - Roh, B.H.

AU - Wing, M.R.

AU - Sandy An, S.

AU - Hester, J.M.

AU - Cooke, J.N.

AU - Bostrom, M.A.

AU - Rudock, M.E.

AU - Talbert, M.E.

AU - Lewis, J.P.

AU - Hottenga, J.J.

AU - de Geus, E.J.C.

AU - Willemsen, G.

AU - Boomsma, D.I.

AU - Ferrara, A.

AU - Lu, L.

AU - Ziegler, J.T.

AU - Sale, M.M.

AU - Divers, J.

AU - Shriner, D.

AU - Adeyemo, A.

AU - Rotimi, C.N.

AU - Ng, M.C.Y.

AU - Langefeld, C.D.

AU - Freedman, B.I.

AU - Bowden, D.W.

AU - Posthuma, D.

AU - Penninx, B.W.J.H.

AU - Sladek, R.

PY - 2012

Y1 - 2012

N2 - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10

AB - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10

U2 - 10.1371/journal.pone.0029202

DO - 10.1371/journal.pone.0029202

M3 - Article

SN - 1932-6203

VL - 7

SP - e29202

JO - PLoS ONE

JF - PLoS ONE

IS - 1

M1 - e29202

ER -

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

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Cohort Studies

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