A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

I. Surakka; J.B. Whitfield; M. Perola; P.M. Visscher; G.W. Montgomery; M. Falchi; G. Willemsen; E.J.C. de Geus; P.K.E. Magnusson; K. Christensen; T.I.A. Sørensen; K.H. Pietilainen; T. Rantanen; K. Silander; E. Widen; J. Muilu; I. Rahman; U. Liljedahl; A.C. Syvänen; A. Palotie; J. Kaprio; K.O. Kyvik; N.L. Pedersen; D.I. Boomsma; T.D. Spector; N.G. Martin; S. Ripatti; L. Peltonen

doi:10.1017/thg.2012.63

A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

I. Surakka, J.B. Whitfield, M. Perola, P.M. Visscher, G.W. Montgomery, M. Falchi, G. Willemsen, E.J.C. de Geus, P.K.E. Magnusson, K. Christensen, T.I.A. Sørensen, K.H. Pietilainen, T. Rantanen, K. Silander, E. Widen, J. Muilu, I. Rahman, U. Liljedahl, A.C. Syvänen, A. PalotieJ. Kaprio, K.O. Kyvik, N.L. Pedersen, D.I. Boomsma, T.D. Spector, N.G. Martin, S. Ripatti, L. Peltonen

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10

Original language	English
Pages (from-to)	691-699
Journal	Twin Research and Human Genetics
Volume	15
Issue number	6
DOIs	https://doi.org/10.1017/thg.2012.63
Publication status	Published - 2012

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Surakka, I., Whitfield, J. B., Perola, M., Visscher, P. M., Montgomery, G. W., Falchi, M., Willemsen, G., de Geus, E. J. C., Magnusson, P. K. E., Christensen, K., Sørensen, T. I. A., Pietilainen, K. H., Rantanen, T., Silander, K., Widen, E., Muilu, J., Rahman, I., Liljedahl, U., Syvänen, A. C., ... Peltonen, L. (2012). A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol. Twin Research and Human Genetics, 15(6), 691-699. https://doi.org/10.1017/thg.2012.63

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title = "A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol",

abstract = "Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10",

author = "I. Surakka and J.B. Whitfield and M. Perola and P.M. Visscher and G.W. Montgomery and M. Falchi and G. Willemsen and {de Geus}, E.J.C. and P.K.E. Magnusson and K. Christensen and T.I.A. S{\o}rensen and K.H. Pietilainen and T. Rantanen and K. Silander and E. Widen and J. Muilu and I. Rahman and U. Liljedahl and A.C. Syv{\"a}nen and A. Palotie and J. Kaprio and K.O. Kyvik and N.L. Pedersen and D.I. Boomsma and T.D. Spector and N.G. Martin and S. Ripatti and L. Peltonen",

year = "2012",

doi = "10.1017/thg.2012.63",

language = "English",

volume = "15",

pages = "691--699",

journal = "Twin Research and Human Genetics",

issn = "1832-4274",

publisher = "Cambridge University Press",

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Surakka, I, Whitfield, JB, Perola, M, Visscher, PM, Montgomery, GW, Falchi, M, Willemsen, G, de Geus, EJC, Magnusson, PKE, Christensen, K, Sørensen, TIA, Pietilainen, KH, Rantanen, T, Silander, K, Widen, E, Muilu, J, Rahman, I, Liljedahl, U, Syvänen, AC, Palotie, A, Kaprio, J, Kyvik, KO, Pedersen, NL, Boomsma, DI, Spector, TD, Martin, NG, Ripatti, S & Peltonen, L 2012, 'A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol', Twin Research and Human Genetics, vol. 15, no. 6, pp. 691-699. https://doi.org/10.1017/thg.2012.63

TY - JOUR

T1 - A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

AU - Surakka, I.

AU - Whitfield, J.B.

AU - Perola, M.

AU - Visscher, P.M.

AU - Montgomery, G.W.

AU - Falchi, M.

AU - Willemsen, G.

AU - de Geus, E.J.C.

AU - Magnusson, P.K.E.

AU - Christensen, K.

AU - Sørensen, T.I.A.

AU - Pietilainen, K.H.

AU - Rantanen, T.

AU - Silander, K.

AU - Widen, E.

AU - Muilu, J.

AU - Rahman, I.

AU - Liljedahl, U.

AU - Syvänen, A.C.

AU - Palotie, A.

AU - Kaprio, J.

AU - Kyvik, K.O.

AU - Pedersen, N.L.

AU - Boomsma, D.I.

AU - Spector, T.D.

AU - Martin, N.G.

AU - Ripatti, S.

AU - Peltonen, L.

PY - 2012

Y1 - 2012

N2 - Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10

AB - Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10

U2 - 10.1017/thg.2012.63

DO - 10.1017/thg.2012.63

M3 - Article

SN - 1832-4274

VL - 15

SP - 691

EP - 699

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

IS - 6

ER -

A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

Abstract

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