A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

I. Surakka; J.B. Whitfield; M. Perola; P.M. Visscher; G.W. Montgomery; M. Falchi; G. Willemsen; E.J.C. de Geus; P.K.E. Magnusson; K. Christensen; T.I.A. Sørensen; K.H. Pietilainen; T. Rantanen; K. Silander; E. Widen; J. Muilu; I. Rahman; U. Liljedahl; A.C. Syvänen; A. Palotie; J. Kaprio; K.O. Kyvik; N.L. Pedersen; D.I. Boomsma; T.D. Spector; N.G. Martin; S. Ripatti; L. Peltonen

doi:10.1017/thg.2012.63

A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

I. Surakka
, J.B. Whitfield
, M. Perola
, P.M. Visscher
, G.W. Montgomery
, M. Falchi
, G. Willemsen
, E.J.C. de Geus
, P.K.E. Magnusson
, K. Christensen
, T.I.A. Sørensen
, K.H. Pietilainen
, T. Rantanen
, K. Silander
, E. Widen
, J. Muilu
, I. Rahman
, U. Liljedahl
, A.C. Syvänen
, A. Palotie

J. Kaprio, K.O. Kyvik, N.L. Pedersen, D.I. Boomsma, T.D. Spector, N.G. Martin, S. Ripatti, L. Peltonen

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10

Original language	English
Pages (from-to)	691-699
Journal	Twin Research and Human Genetics
Volume	15
Issue number	6
DOIs	https://doi.org/10.1017/thg.2012.63
Publication status	Published - 2012

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10.1017/thg.2012.63

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Surakka, I., Whitfield, J. B., Perola, M., Visscher, P. M., Montgomery, G. W., Falchi, M., Willemsen, G., de Geus, E. J. C., Magnusson, P. K. E., Christensen, K., Sørensen, T. I. A., Pietilainen, K. H., Rantanen, T., Silander, K., Widen, E., Muilu, J., Rahman, I., Liljedahl, U., Syvänen, A. C., ... Peltonen, L. (2012). A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol. Twin Research and Human Genetics, 15(6), 691-699. https://doi.org/10.1017/thg.2012.63

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title = "A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol",

abstract = "Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10",

author = "I. Surakka and J.B. Whitfield and M. Perola and P.M. Visscher and G.W. Montgomery and M. Falchi and G. Willemsen and \{de Geus\}, E.J.C. and P.K.E. Magnusson and K. Christensen and T.I.A. S{\o}rensen and K.H. Pietilainen and T. Rantanen and K. Silander and E. Widen and J. Muilu and I. Rahman and U. Liljedahl and A.C. Syv{\"a}nen and A. Palotie and J. Kaprio and K.O. Kyvik and N.L. Pedersen and D.I. Boomsma and T.D. Spector and N.G. Martin and S. Ripatti and L. Peltonen",

year = "2012",

doi = "10.1017/thg.2012.63",

language = "English",

volume = "15",

pages = "691--699",

journal = "Twin Research and Human Genetics",

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Surakka, I, Whitfield, JB, Perola, M, Visscher, PM, Montgomery, GW, Falchi, M, Willemsen, G, de Geus, EJC, Magnusson, PKE, Christensen, K, Sørensen, TIA, Pietilainen, KH, Rantanen, T, Silander, K, Widen, E, Muilu, J, Rahman, I, Liljedahl, U, Syvänen, AC, Palotie, A, Kaprio, J, Kyvik, KO, Pedersen, NL, Boomsma, DI, Spector, TD, Martin, NG, Ripatti, S & Peltonen, L 2012, 'A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol', Twin Research and Human Genetics, vol. 15, no. 6, pp. 691-699. https://doi.org/10.1017/thg.2012.63

TY - JOUR

T1 - A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

AU - Surakka, I.

AU - Whitfield, J.B.

AU - Perola, M.

AU - Visscher, P.M.

AU - Montgomery, G.W.

AU - Falchi, M.

AU - Willemsen, G.

AU - de Geus, E.J.C.

AU - Magnusson, P.K.E.

AU - Christensen, K.

AU - Sørensen, T.I.A.

AU - Pietilainen, K.H.

AU - Rantanen, T.

AU - Silander, K.

AU - Widen, E.

AU - Muilu, J.

AU - Rahman, I.

AU - Liljedahl, U.

AU - Syvänen, A.C.

AU - Palotie, A.

AU - Kaprio, J.

AU - Kyvik, K.O.

AU - Pedersen, N.L.

AU - Boomsma, D.I.

AU - Spector, T.D.

AU - Martin, N.G.

AU - Ripatti, S.

AU - Peltonen, L.

PY - 2012

Y1 - 2012

N2 - Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10

AB - Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10

U2 - 10.1017/thg.2012.63

DO - 10.1017/thg.2012.63

M3 - Article

SN - 1832-4274

VL - 15

SP - 691

EP - 699

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

IS - 6

ER -

A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol

Abstract

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