A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation

K. Estrada, M. Krawczak, S Schreiber, K. van Duijn, L. Stolk, J.B.J. van Meurs, F. Liu, B.W.J.H. Penninx, J.H. Smit, N. Vogelzangs, J.J. Hottenga, G. Willemsen, E.J.C. de Geus, M. Lorentzon, H. von Eller-Eberstein, P.T.A.M. Lips, N.M. van Schoor, V. Pop, J. de Keijzer, A. HofmanY.S. Aulchenko, B.A. Oostra, C. Ohlsson, D.I. Boomsma, A.G. Uitterlinden, C.M. van Duijn, F.F. Rivadeneira, M. Kayser

Research output: Contribution to JournalArticle

Abstract

Northwestern Europeans are among the tallest of human populations. The increase in body height in these people appears to have reached a plateau, suggesting the ubiquitous presence of an optimal environment in which genetic factors may have exerted a particularly strong influence on human growth. Therefore, we performed a genome-wide association study (GWAS) of body height using 2.2 million markers in 10 074 individuals from three Dutch and one German population-based cohorts. Upon genotyping, the 12 most significantly height-associated single nucleotide polymorphisms (SNPs) from this GWAS in 6912 additional individuals of Dutch and Swedish origin, a genetic variant (rs6717918) on chromosome 2q37.1 was found to be associated with height at a genome-wide significance level (P
Original languageEnglish
Pages (from-to)3516-3524
JournalHuman Molecular Genetics
Volume18
Issue number18
DOIs
Publication statusPublished - 2009

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