TY - JOUR
T1 - A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
AU - Lind, P.A.
AU - Macgregor, S.
AU - Vink, J.M.
AU - Pergadia, M.L.
AU - Hansell, N.
AU - de Moor, M.H.M.
AU - Smit, A.B.
AU - Hottenga, J.J.
AU - Richter, M.
AU - Heath, A.C.
AU - Martin, N.G.
AU - Willemsen, G.
AU - de Geus, E.J.C.
AU - Vogelzangs, N.
AU - Penninx, B.W.J.H.
AU - Whitfield, J.B.
AU - Montgomery, GW
AU - Boomsma, D.I.
AU - Madden, P.A.F.
PY - 2010
Y1 - 2010
N2 - Persistent tobacco use and excessive alcohol consumption are major public health concerns worldwide. Both alcohol and nicotine dependence (AD, ND) are genetically influenced complex disorders that exhibit a high degree of comorbidity. To identify gene variants contributing to one or both of these addictions, we first conducted a pooling-based genomewide association study (GWAS) in an Australian population, using Illumina Infinium 1M arrays. Allele frequency differences were compared between pooled DNA from case and control groups for: (1) AD, 1224 cases and 1162 controls; (2) ND, 1273 cases and 1113 controls; and (3) comorbid AD and ND, 599 cases and 488 controls. Secondly, we carried out a GWAS in independent samples from the Netherlands for AD and for ND. Thirdly, we performed a meta-analysis of the 10,000 most significant AD- and ND-related SNPs from the Australian and Dutch samples. In the Australian GWAS, one SNP achieved genomewide significance ( p < 5 × 10
AB - Persistent tobacco use and excessive alcohol consumption are major public health concerns worldwide. Both alcohol and nicotine dependence (AD, ND) are genetically influenced complex disorders that exhibit a high degree of comorbidity. To identify gene variants contributing to one or both of these addictions, we first conducted a pooling-based genomewide association study (GWAS) in an Australian population, using Illumina Infinium 1M arrays. Allele frequency differences were compared between pooled DNA from case and control groups for: (1) AD, 1224 cases and 1162 controls; (2) ND, 1273 cases and 1113 controls; and (3) comorbid AD and ND, 599 cases and 488 controls. Secondly, we carried out a GWAS in independent samples from the Netherlands for AD and for ND. Thirdly, we performed a meta-analysis of the 10,000 most significant AD- and ND-related SNPs from the Australian and Dutch samples. In the Australian GWAS, one SNP achieved genomewide significance ( p < 5 × 10
U2 - 10.1375/twin.13.1.10
DO - 10.1375/twin.13.1.10
M3 - Article
VL - 13
SP - 10
EP - 29
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
SN - 1832-4274
IS - 1
ER -
