A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model

G.L. de Lange; J.R. Overman; E. Farre-Guasch; C.M. Korstjens; B. Hartman; G.E.J. Langenbach; M.A. van Duin; J. Klein-Nulend

doi:10.1016/j.oooo.2013.08.008

A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model

G.L. de Lange, J.R. Overman, E. Farre-Guasch, C.M. Korstjens, B. Hartman, G.E.J. Langenbach, M.A. van Duin, J. Klein-Nulend

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objective
The gain of mineralized bone was compared between deproteinized bovine bone allograft (DBA) and biphasic calcium phosphate (BCP) for dental implant placement.

Study Design
Five patients with atrophic maxillae underwent bilateral sinus elevation with DBA (Bio-Oss) and BCP (Straumann BoneCeramic). After 3 to 8 months, 32 Camlog implants were placed, and biopsies were retrieved. Bone and graft volume, degree of bone mineralization, and graft degradation gradient were determined using micro-computed tomography, and bone formation and resorption parameters were measured using histomorphometry. Implant functioning and peri-implant mucosa were evaluated up to 4 years.

Results
Patients were prosthetically successfully restored. All but one of the implants survived, and peri-implant mucosa showed healthy appearance and stability. Bone volume, graft volume, degree of bone mineralization, and osteoclast and osteocyte numbers were similar, but BCP-grafted biopsies had relatively more osteoid than DBA-grafted biopsies.

Conclusions
The BCP and DBA materials showed similar osteoconductive patterns and mineralized bone, although signs of more active bone formation and remodeling were observed in BCP- than in DBA-grafted biopsies.

Original language	English
Pages (from-to)	8-22
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	117
Issue number	1
DOIs	https://doi.org/10.1016/j.oooo.2013.08.008
Publication status	Published - 2014

Access to Document

10.1016/j.oooo.2013.08.008

Persistent URL (handle)

Persistent link

Fingerprint

Dive into the research topics of 'A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model'. Together they form a unique fingerprint.

Cite this

de Lange, G. L., Overman, J. R., Farre-Guasch, E., Korstjens, C. M., Hartman, B., Langenbach, G. E. J., van Duin, M. A., & Klein-Nulend, J. (2014). A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 117(1), 8-22. https://doi.org/10.1016/j.oooo.2013.08.008

@article{41300e84fe114e478518df6be7dbcc49,

title = "A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model",

abstract = "Objective The gain of mineralized bone was compared between deproteinized bovine bone allograft (DBA) and biphasic calcium phosphate (BCP) for dental implant placement. Study Design Five patients with atrophic maxillae underwent bilateral sinus elevation with DBA (Bio-Oss) and BCP (Straumann BoneCeramic). After 3 to 8 months, 32 Camlog implants were placed, and biopsies were retrieved. Bone and graft volume, degree of bone mineralization, and graft degradation gradient were determined using micro-computed tomography, and bone formation and resorption parameters were measured using histomorphometry. Implant functioning and peri-implant mucosa were evaluated up to 4 years. Results Patients were prosthetically successfully restored. All but one of the implants survived, and peri-implant mucosa showed healthy appearance and stability. Bone volume, graft volume, degree of bone mineralization, and osteoclast and osteocyte numbers were similar, but BCP-grafted biopsies had relatively more osteoid than DBA-grafted biopsies. Conclusions The BCP and DBA materials showed similar osteoconductive patterns and mineralized bone, although signs of more active bone formation and remodeling were observed in BCP- than in DBA-grafted biopsies.",

author = "\{de Lange\}, G.L. and J.R. Overman and E. Farre-Guasch and C.M. Korstjens and B. Hartman and G.E.J. Langenbach and \{van Duin\}, M.A. and J. Klein-Nulend",

year = "2014",

doi = "10.1016/j.oooo.2013.08.008",

language = "English",

volume = "117",

pages = "8--22",

journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",

issn = "2212-4403",

publisher = "Elsevier Inc.",

number = "1",

}

de Lange, GL, Overman, JR, Farre-Guasch, E, Korstjens, CM, Hartman, B, Langenbach, GEJ, van Duin, MA & Klein-Nulend, J 2014, 'A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 117, no. 1, pp. 8-22. https://doi.org/10.1016/j.oooo.2013.08.008

A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model. / de Lange, G.L.; Overman, J.R.; Farre-Guasch, E. et al.
In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 117, No. 1, 2014, p. 8-22.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model

AU - de Lange, G.L.

AU - Overman, J.R.

AU - Farre-Guasch, E.

AU - Korstjens, C.M.

AU - Hartman, B.

AU - Langenbach, G.E.J.

AU - van Duin, M.A.

AU - Klein-Nulend, J.

PY - 2014

Y1 - 2014

N2 - Objective The gain of mineralized bone was compared between deproteinized bovine bone allograft (DBA) and biphasic calcium phosphate (BCP) for dental implant placement. Study Design Five patients with atrophic maxillae underwent bilateral sinus elevation with DBA (Bio-Oss) and BCP (Straumann BoneCeramic). After 3 to 8 months, 32 Camlog implants were placed, and biopsies were retrieved. Bone and graft volume, degree of bone mineralization, and graft degradation gradient were determined using micro-computed tomography, and bone formation and resorption parameters were measured using histomorphometry. Implant functioning and peri-implant mucosa were evaluated up to 4 years. Results Patients were prosthetically successfully restored. All but one of the implants survived, and peri-implant mucosa showed healthy appearance and stability. Bone volume, graft volume, degree of bone mineralization, and osteoclast and osteocyte numbers were similar, but BCP-grafted biopsies had relatively more osteoid than DBA-grafted biopsies. Conclusions The BCP and DBA materials showed similar osteoconductive patterns and mineralized bone, although signs of more active bone formation and remodeling were observed in BCP- than in DBA-grafted biopsies.

AB - Objective The gain of mineralized bone was compared between deproteinized bovine bone allograft (DBA) and biphasic calcium phosphate (BCP) for dental implant placement. Study Design Five patients with atrophic maxillae underwent bilateral sinus elevation with DBA (Bio-Oss) and BCP (Straumann BoneCeramic). After 3 to 8 months, 32 Camlog implants were placed, and biopsies were retrieved. Bone and graft volume, degree of bone mineralization, and graft degradation gradient were determined using micro-computed tomography, and bone formation and resorption parameters were measured using histomorphometry. Implant functioning and peri-implant mucosa were evaluated up to 4 years. Results Patients were prosthetically successfully restored. All but one of the implants survived, and peri-implant mucosa showed healthy appearance and stability. Bone volume, graft volume, degree of bone mineralization, and osteoclast and osteocyte numbers were similar, but BCP-grafted biopsies had relatively more osteoid than DBA-grafted biopsies. Conclusions The BCP and DBA materials showed similar osteoconductive patterns and mineralized bone, although signs of more active bone formation and remodeling were observed in BCP- than in DBA-grafted biopsies.

UR - https://www.scopus.com/pages/publications/84890425177

UR - https://www.scopus.com/inward/citedby.url?scp=84890425177&partnerID=8YFLogxK

U2 - 10.1016/j.oooo.2013.08.008

DO - 10.1016/j.oooo.2013.08.008

M3 - Article

SN - 2212-4403

VL - 117

SP - 8

EP - 22

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

IS - 1

ER -

de Lange GL, Overman JR, Farre-Guasch E, Korstjens CM, Hartman B, Langenbach GEJ et al. A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014;117(1):8-22. doi: 10.1016/j.oooo.2013.08.008

A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model

Abstract

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this