A mathematical model that accounts for the effects of caloric restriction on body weight and longevity.

I.M.M. van Leeuwen, F.L.D. Kelpin, S.A.L.M. Kooijman

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Several aspects of energy dynamics, such as energy expenditure and caloric intake, are known to affect the aging process. In this article we therefore model the aging process within a mathematical framework describing the energy dynamics of an organism. The resulting model comprises food intake, body growth and survival. The equation for the mortality rate accounts for food consumption and is suited to describe caloric restriction data. For non-growing animals, the expression for the mortality rate reduces to the well-known Gompertz equation. We successfully applied our model to growth and survival data on mice exposed to different food levels.
Original languageEnglish
Pages (from-to)373-381
JournalBiogerontology
Volume3
DOIs
Publication statusPublished - 2002

Fingerprint

Dive into the research topics of 'A mathematical model that accounts for the effects of caloric restriction on body weight and longevity.'. Together they form a unique fingerprint.

Cite this