This meta-analysis, including six studies (13 effect sizes) and 164 adolescents, examined the effectiveness of individually oriented treatment (which means that the intervention contained at least an individual component, possibly in combination with group and/or family therapy) with CBT-elements for adolescents with severe aggression problems. A large and homogeneous overall effect size was found (d = 1.139) indicating consistency across studies. The included studies examined the effect of three interventions, namely, mode deactivation therapy (MDT; four studies), stress-inoculation therapy (1), and the cell-phone program (1). This multilevel analysis demonstrated that only few individually oriented interventions have been developed and evaluated, while four of the included studies used a weak research design. Effective individually tailored interventions for youths with severe aggression problems (who are unsuitable for group treatment) are scant. There may be added value if group interventions are supplemented with more individually tailored evidence-based interventions.