A method for nitric oxide radical scavenging properties of sulfur containing compounds.

M.F. Vriesman; G.R.M.M. Haenen; G.J. Westerveld; J.B.G. Paquay; H.P. Voss; A. Bast

doi:10.1023/A:1008601327920

A method for nitric oxide radical scavenging properties of sulfur containing compounds.

M.F. Vriesman
, G.R.M.M. Haenen
, G.J. Westerveld
, J.B.G. Paquay
, H.P. Voss
, A. Bast

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A new method for the quantification of the nitric oxide (<dot>NO) scavenging activity of compounds in aqueous solutions is described using an amperometric <dot>NO sensor. After correction for the spontaneous degradation of <dot>NO, second-order rate kinetics of the scavenging reaction are observed. The rate constant for haemoglobin found with this method is comparable with that found with an established spectrophotometric method. To demonstrate the capability of the method, several sulfur-containing compounds were tested (GSH, GSSG, S-methyl glutathione, N-acetyl cysteine, lipoic acid and dihydrolipoic acid). Of these compounds, only those that contained a thiol group displayed a considerable <dot>NO scavenging activity.

Original language	English
Pages (from-to)	283-286
Journal	Pharmacy World and Science
Volume	19
DOIs	https://doi.org/10.1023/A:1008601327920
Publication status	Published - 1997

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10.1023/A:1008601327920

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title = "A method for nitric oxide radical scavenging properties of sulfur containing compounds.",

abstract = "A new method for the quantification of the nitric oxide (NO) scavenging activity of compounds in aqueous solutions is described using an amperometric NO sensor. After correction for the spontaneous degradation of NO, second-order rate kinetics of the scavenging reaction are observed. The rate constant for haemoglobin found with this method is comparable with that found with an established spectrophotometric method. To demonstrate the capability of the method, several sulfur-containing compounds were tested (GSH, GSSG, S-methyl glutathione, N-acetyl cysteine, lipoic acid and dihydrolipoic acid). Of these compounds, only those that contained a thiol group displayed a considerable NO scavenging activity.",

author = "M.F. Vriesman and G.R.M.M. Haenen and G.J. Westerveld and J.B.G. Paquay and H.P. Voss and A. Bast",

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T1 - A method for nitric oxide radical scavenging properties of sulfur containing compounds.

AU - Vriesman, M.F.

AU - Haenen, G.R.M.M.

AU - Westerveld, G.J.

AU - Paquay, J.B.G.

AU - Voss, H.P.

AU - Bast, A.

PY - 1997

Y1 - 1997

N2 - A new method for the quantification of the nitric oxide (NO) scavenging activity of compounds in aqueous solutions is described using an amperometric NO sensor. After correction for the spontaneous degradation of NO, second-order rate kinetics of the scavenging reaction are observed. The rate constant for haemoglobin found with this method is comparable with that found with an established spectrophotometric method. To demonstrate the capability of the method, several sulfur-containing compounds were tested (GSH, GSSG, S-methyl glutathione, N-acetyl cysteine, lipoic acid and dihydrolipoic acid). Of these compounds, only those that contained a thiol group displayed a considerable NO scavenging activity.

AB - A new method for the quantification of the nitric oxide (NO) scavenging activity of compounds in aqueous solutions is described using an amperometric NO sensor. After correction for the spontaneous degradation of NO, second-order rate kinetics of the scavenging reaction are observed. The rate constant for haemoglobin found with this method is comparable with that found with an established spectrophotometric method. To demonstrate the capability of the method, several sulfur-containing compounds were tested (GSH, GSSG, S-methyl glutathione, N-acetyl cysteine, lipoic acid and dihydrolipoic acid). Of these compounds, only those that contained a thiol group displayed a considerable NO scavenging activity.

U2 - 10.1023/A:1008601327920

DO - 10.1023/A:1008601327920

M3 - Article

SN - 0928-1231

VL - 19

SP - 283

EP - 286

JO - Pharmacy World and Science

JF - Pharmacy World and Science

ER -

A method for nitric oxide radical scavenging properties of sulfur containing compounds.

Abstract

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