A Mild Chemo-Enzymatic Oxidation-Hydrocyanation Cascade

D.J. Vugts, L. Veum, K. Al-Mafraji, R.H. Lemmens, R.F. Schmitz, F.J.J. de Kanter, M.B. Groen, U. Hanefeld, Orru R.V.A.

Research output: Contribution to JournalArticleAcademicpeer-review


Oxidation-hydrocyanation of γ,δ-unsaturated alcohols using (immobilised) TEMPOXPhI(OAc)2 in combination with HbHNL proceeds smoothly. After (in situ) protection, the resulting cyanohydrin derivatives were obtained in good overall yields and high ee's. A mild TEMPO-catalysed oxidation protocol is described that yields β,γ-unsaturated aldehydes without isomerisation of the double bond and that is compatible with a subsequent HbHNL-catalysed hydrocyanation performed in the same solvent system. © Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Original languageEnglish
Pages (from-to)1672
JournalEuropean Journal of Organic Chemistry
Publication statusPublished - 2006


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