Abstract
A study was conducted to demonstrate multicomponent reactions (MCR) towards N-(cyanomethyl)amides. A fourth MCR was developed from α-isocyano amides, amines, and carbonyl components. It was demonstrated that the resulting N-(cyanomethyl)amides were to be isolated in moderate to excellent yield using a wide range of primary and secondary amines, along with aldehydes and ketones. A number of functional groups were tolerated in addition to the broad substrate scope of the reaction, eliminating the need for protective groups and allowing direct post-modification. The results of the reaction were also directed toward 2H-2-imidazolines by modifying reaction conditions. The α-isocyano amides, aldehydes or ketones, and amines were stirred in MeOH in the presence of MgSO
Original language | English |
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Pages (from-to) | 6096-6099 |
Number of pages | 4 |
Journal | Chemistry: A European Journal |
Volume | 15 |
Issue number | 25 |
Early online date | 5 Jun 2009 |
DOIs | |
Publication status | Published - 15 Jun 2009 |
Keywords
- Amides/chemical synthesis
- Catalysis
- Imidazolines/chemistry
- Molecular Structure
- Nitriles/chemical synthesis
- Silver/chemistry
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CCDC 735704: Experimental Crystal Structure Determination
Elders, N. (Contributor), Ruijter, E. (Contributor), De Kanter, F. J. J. (Contributor), Janssen, E. (Contributor), Lutz, M. (Contributor), Spek, A. L. (Contributor) & Orru, R. V. A. (Contributor), Unknown Publisher, 15 Jun 2009
DOI: 10.5517/ccspkdd, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccspkdd&sid=DataCite
Dataset / Software: Dataset