A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines

D. Coffinier; L. El Kaim; L. Grimaud; E. Ruijter; R.V.A. Orru

doi:10.1016/j.tetlet.2011.04.007

A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines

D. Coffinier, L. El Kaim, L. Grimaud, E. Ruijter, R.V.A. Orru

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Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The ketenimines resulting from a Nef isocyanide/Perkow sequence react with 1-azadienes to form pyridines or pyrimidines depending on their substitution pattern. The reaction is most efficient with ester-substituted ketenimines which leads to pyridines after elimination of the phosphate group. © 2011 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	3023-3025
Journal	Tetrahedron Letters
Volume	52
Issue number	23
DOIs	https://doi.org/10.1016/j.tetlet.2011.04.007
Publication status	Published - 2011

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10.1016/j.tetlet.2011.04.007

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title = "A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines",

abstract = "The ketenimines resulting from a Nef isocyanide/Perkow sequence react with 1-azadienes to form pyridines or pyrimidines depending on their substitution pattern. The reaction is most efficient with ester-substituted ketenimines which leads to pyridines after elimination of the phosphate group. {\textcopyright} 2011 Elsevier Ltd. All rights reserved.",

author = "D. Coffinier and {El Kaim}, L. and L. Grimaud and E. Ruijter and R.V.A. Orru",

year = "2011",

doi = "10.1016/j.tetlet.2011.04.007",

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T1 - A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines

AU - Coffinier, D.

AU - El Kaim, L.

AU - Grimaud, L.

AU - Ruijter, E.

AU - Orru, R.V.A.

PY - 2011

Y1 - 2011

N2 - The ketenimines resulting from a Nef isocyanide/Perkow sequence react with 1-azadienes to form pyridines or pyrimidines depending on their substitution pattern. The reaction is most efficient with ester-substituted ketenimines which leads to pyridines after elimination of the phosphate group. © 2011 Elsevier Ltd. All rights reserved.

AB - The ketenimines resulting from a Nef isocyanide/Perkow sequence react with 1-azadienes to form pyridines or pyrimidines depending on their substitution pattern. The reaction is most efficient with ester-substituted ketenimines which leads to pyridines after elimination of the phosphate group. © 2011 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tetlet.2011.04.007

DO - 10.1016/j.tetlet.2011.04.007

M3 - Article

SN - 0040-4039

VL - 52

SP - 3023

EP - 3025

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 23

ER -

A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines

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