A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines

D. Coffinier, L. El Kaim, L. Grimaud, E. Ruijter, R.V.A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The ketenimines resulting from a Nef isocyanide/Perkow sequence react with 1-azadienes to form pyridines or pyrimidines depending on their substitution pattern. The reaction is most efficient with ester-substituted ketenimines which leads to pyridines after elimination of the phosphate group. © 2011 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)3023-3025
JournalTetrahedron Letters
Volume52
Issue number23
DOIs
Publication statusPublished - 2011

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