A novel common variant in DCST2 is associated with length in early life and height in adulthood

R.J.P. van der Valk, E. Kreiner-Moller, M.N. Kooijman, M. Guxens, E. Stergiakouli, A. Saaf, J.P. Bradfield, F. Geller, M.G. Hayes, D.L. Cousminer, A. Koerner, E. Thiering, J.A. Curtin, R. Myhre, V. Huikari, R. Joro, M. Kerkhof, N.M. Warrington, N. Pitkanen, I. NtallaM. Horikoshi, R. Veijola, R.M. Freathy, Y. Teo, S.J. Barton, D.M. Evans, J.P. Kemp, B. St Pourcain, S.M. Ring, G.D. Smith, A. Bergstrom, I. Kull, H. Hakonarson, F.D. Mentch, H. Bisgaard, B. Chawes, J. Stokholm, J. Waage, P. Eriksen, A. Sevelsted, M. Melbye, C.M. van Duijn, C. Medina-Gomez, A. Hofman, J.C. de Jongste, H.R. Taal, A. G. Uitterlinden, L.L. Armstrong, J. Eriksson, A. Palotie, M. Bustamante, X. Estivill, J.R. Gonzalez, S. Llop, W. Kiess, A. Mahajan, C. Flexeder, C.M.T. Tiesler, C.S. Murray, A. Simpson, P. Magnus, V. Sengpiel, A. Hartikainen, S. Keinanen-Kiukaanniemi, A. Lewin, A.D.S.C. Alves, A.I. Blakemore, J.L. Buxton, M. Kaakinen, A. Rodriguez, S. Sebert, M. Vaarasmaki, T. Lakka, V. Lindi, U. Gehring, D.S. Postma, W. Ang, J.P. Newnham, L. Lyytikainen, K. Pahkala, O.T. Raitakari, K. Panoutsopoulou, E. Zeggini, D.I. Boomsma, M.M. Groen-Blokhuis, J. Ilonen, L. Franke, J.N. Hirschhorn, T.H. Pers, L. Liang, J. Huang, B. Hocher, M. Knip, S. Saw, J.W. Holloway, E. Melen, S.F.A. Grant, B. Feenstra, W.L. Lowe, E. Widen, E. Sergeyev, H. Grallert, A. Custovic, B. Jacobsson, M. Jarvelin, M. Atalay, G.H. Koppelman, C.E. Pennell, H. Niinikoski, G.V. Dedoussis, M.I. McCarthy, T.M. Frayling, J. Sunyer, N.J. Timpson, F. Rivadeneira, K. Bonnelykke, V.W.V. Jaddoe

Research output: Contribution to JournalArticleAcademicpeer-review


Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10
Original languageEnglish
Pages (from-to)1155-1168
JournalHuman Molecular Genetics
Issue number4
Publication statusPublished - 2015

Bibliographical note

PT: J; UT: WOS:000350138300021

Cohort Studies

  • Netherlands Twin Register (NTR)


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