A novel common variant in DCST2 is associated with length in early life and height in adulthood

R.J.P. van der Valk; E. Kreiner-Moller; M.N. Kooijman; M. Guxens; E. Stergiakouli; A. Saaf; J.P. Bradfield; F. Geller; M.G. Hayes; D.L. Cousminer; A. Koerner; E. Thiering; J.A. Curtin; R. Myhre; V. Huikari; R. Joro; M. Kerkhof; N.M. Warrington; N. Pitkanen; I. Ntalla; M. Horikoshi; R. Veijola; R.M. Freathy; Y. Teo; S.J. Barton; D.M. Evans; J.P. Kemp; B. St Pourcain; S.M. Ring; G.D. Smith; A. Bergstrom; I. Kull; H. Hakonarson; F.D. Mentch; H. Bisgaard; B. Chawes; J. Stokholm; J. Waage; P. Eriksen; A. Sevelsted; M. Melbye; C.M. van Duijn; C. Medina-Gomez; A. Hofman; J.C. de Jongste; H.R. Taal; A. G. Uitterlinden; L.L. Armstrong; J. Eriksson; A. Palotie; M. Bustamante; X. Estivill; J.R. Gonzalez; S. Llop; W. Kiess; A. Mahajan; C. Flexeder; C.M.T. Tiesler; C.S. Murray; A. Simpson; P. Magnus; V. Sengpiel; A. Hartikainen; S. Keinanen-Kiukaanniemi; A. Lewin; A.D.S.C. Alves; A.I. Blakemore; J.L. Buxton; M. Kaakinen; A. Rodriguez; S. Sebert; M. Vaarasmaki; T. Lakka; V. Lindi; U. Gehring; D.S. Postma; W. Ang; J.P. Newnham; L. Lyytikainen; K. Pahkala; O.T. Raitakari; K. Panoutsopoulou; E. Zeggini; D.I. Boomsma; M.M. Groen-Blokhuis; J. Ilonen; L. Franke; J.N. Hirschhorn; T.H. Pers; L. Liang; J. Huang; B. Hocher; M. Knip; S. Saw; J.W. Holloway; E. Melen; S.F.A. Grant; B. Feenstra; W.L. Lowe; E. Widen; E. Sergeyev; H. Grallert; A. Custovic; B. Jacobsson; M. Jarvelin; M. Atalay; G.H. Koppelman; C.E. Pennell; H. Niinikoski; G.V. Dedoussis; M.I. McCarthy; T.M. Frayling; J. Sunyer; N.J. Timpson; F. Rivadeneira; K. Bonnelykke; V.W.V. Jaddoe

doi:10.1093/hmg/ddu510

A novel common variant in DCST2 is associated with length in early life and height in adulthood

R.J.P. van der Valk, E. Kreiner-Moller, M.N. Kooijman, M. Guxens, E. Stergiakouli, A. Saaf, J.P. Bradfield, F. Geller, M.G. Hayes, D.L. Cousminer, A. Koerner, E. Thiering, J.A. Curtin, R. Myhre, V. Huikari, R. Joro, M. Kerkhof, N.M. Warrington, N. Pitkanen, I. NtallaM. Horikoshi, R. Veijola, R.M. Freathy, Y. Teo, S.J. Barton, D.M. Evans, J.P. Kemp, B. St Pourcain, S.M. Ring, G.D. Smith, A. Bergstrom, I. Kull, H. Hakonarson, F.D. Mentch, H. Bisgaard, B. Chawes, J. Stokholm, J. Waage, P. Eriksen, A. Sevelsted, M. Melbye, C.M. van Duijn, C. Medina-Gomez, A. Hofman, J.C. de Jongste, H.R. Taal, A. G. Uitterlinden, L.L. Armstrong, J. Eriksson, A. Palotie, M. Bustamante, X. Estivill, J.R. Gonzalez, S. Llop, W. Kiess, A. Mahajan, C. Flexeder, C.M.T. Tiesler, C.S. Murray, A. Simpson, P. Magnus, V. Sengpiel, A. Hartikainen, S. Keinanen-Kiukaanniemi, A. Lewin, A.D.S.C. Alves, A.I. Blakemore, J.L. Buxton, M. Kaakinen, A. Rodriguez, S. Sebert, M. Vaarasmaki, T. Lakka, V. Lindi, U. Gehring, D.S. Postma, W. Ang, J.P. Newnham, L. Lyytikainen, K. Pahkala, O.T. Raitakari, K. Panoutsopoulou, E. Zeggini, D.I. Boomsma, M.M. Groen-Blokhuis, J. Ilonen, L. Franke, J.N. Hirschhorn, T.H. Pers, L. Liang, J. Huang, B. Hocher, M. Knip, S. Saw, J.W. Holloway, E. Melen, S.F.A. Grant, B. Feenstra, W.L. Lowe, E. Widen, E. Sergeyev, H. Grallert, A. Custovic, B. Jacobsson, M. Jarvelin, M. Atalay, G.H. Koppelman, C.E. Pennell, H. Niinikoski, G.V. Dedoussis, M.I. McCarthy, T.M. Frayling, J. Sunyer, N.J. Timpson, F. Rivadeneira, K. Bonnelykke, V.W.V. Jaddoe

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10

Original language	English
Pages (from-to)	1155-1168
Journal	Human Molecular Genetics
Volume	24
Issue number	4
DOIs	https://doi.org/10.1093/hmg/ddu510
Publication status	Published - 2015

Bibliographical note

PT: J; UT: WOS:000350138300021

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

10.1093/hmg/ddu510

Persistent URL (handle)

Copy link address

Cite this

van der Valk, R. J. P., Kreiner-Moller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Saaf, A., Bradfield, J. P., Geller, F., Hayes, M. G., Cousminer, D. L., Koerner, A., Thiering, E., Curtin, J. A., Myhre, R., Huikari, V., Joro, R., Kerkhof, M., Warrington, N. M., Pitkanen, N., ... Jaddoe, V. W. V. (2015). A novel common variant in DCST2 is associated with length in early life and height in adulthood. Human Molecular Genetics, 24(4), 1155-1168. https://doi.org/10.1093/hmg/ddu510

@article{fa50f2e046114f6d93880a243811b60c,

title = "A novel common variant in DCST2 is associated with length in early life and height in adulthood",

abstract = "Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10",

author = "{van der Valk}, R.J.P. and E. Kreiner-Moller and M.N. Kooijman and M. Guxens and E. Stergiakouli and A. Saaf and J.P. Bradfield and F. Geller and M.G. Hayes and D.L. Cousminer and A. Koerner and E. Thiering and J.A. Curtin and R. Myhre and V. Huikari and R. Joro and M. Kerkhof and N.M. Warrington and N. Pitkanen and I. Ntalla and M. Horikoshi and R. Veijola and R.M. Freathy and Y. Teo and S.J. Barton and D.M. Evans and J.P. Kemp and {St Pourcain}, B. and S.M. Ring and G.D. Smith and A. Bergstrom and I. Kull and H. Hakonarson and F.D. Mentch and H. Bisgaard and B. Chawes and J. Stokholm and J. Waage and P. Eriksen and A. Sevelsted and M. Melbye and {van Duijn}, C.M. and C. Medina-Gomez and A. Hofman and {de Jongste}, J.C. and H.R. Taal and Uitterlinden, {A. G.} and L.L. Armstrong and J. Eriksson and A. Palotie and M. Bustamante and X. Estivill and J.R. Gonzalez and S. Llop and W. Kiess and A. Mahajan and C. Flexeder and C.M.T. Tiesler and C.S. Murray and A. Simpson and P. Magnus and V. Sengpiel and A. Hartikainen and S. Keinanen-Kiukaanniemi and A. Lewin and A.D.S.C. Alves and A.I. Blakemore and J.L. Buxton and M. Kaakinen and A. Rodriguez and S. Sebert and M. Vaarasmaki and T. Lakka and V. Lindi and U. Gehring and D.S. Postma and W. Ang and J.P. Newnham and L. Lyytikainen and K. Pahkala and O.T. Raitakari and K. Panoutsopoulou and E. Zeggini and D.I. Boomsma and M.M. Groen-Blokhuis and J. Ilonen and L. Franke and J.N. Hirschhorn and T.H. Pers and L. Liang and J. Huang and B. Hocher and M. Knip and S. Saw and J.W. Holloway and E. Melen and S.F.A. Grant and B. Feenstra and W.L. Lowe and E. Widen and E. Sergeyev and H. Grallert and A. Custovic and B. Jacobsson and M. Jarvelin and M. Atalay and G.H. Koppelman and C.E. Pennell and H. Niinikoski and G.V. Dedoussis and M.I. McCarthy and T.M. Frayling and J. Sunyer and N.J. Timpson and F. Rivadeneira and K. Bonnelykke and V.W.V. Jaddoe",

note = "PT: J; UT: WOS:000350138300021",

year = "2015",

doi = "10.1093/hmg/ddu510",

language = "English",

volume = "24",

pages = "1155--1168",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "4",

}

van der Valk, RJP, Kreiner-Moller, E, Kooijman, MN, Guxens, M, Stergiakouli, E, Saaf, A, Bradfield, JP, Geller, F, Hayes, MG, Cousminer, DL, Koerner, A, Thiering, E, Curtin, JA, Myhre, R, Huikari, V, Joro, R, Kerkhof, M, Warrington, NM, Pitkanen, N, Ntalla, I, Horikoshi, M, Veijola, R, Freathy, RM, Teo, Y, Barton, SJ, Evans, DM, Kemp, JP, St Pourcain, B, Ring, SM, Smith, GD, Bergstrom, A, Kull, I, Hakonarson, H, Mentch, FD, Bisgaard, H, Chawes, B, Stokholm, J, Waage, J, Eriksen, P, Sevelsted, A, Melbye, M, van Duijn, CM, Medina-Gomez, C, Hofman, A, de Jongste, JC, Taal, HR, Uitterlinden, AG, Armstrong, LL, Eriksson, J, Palotie, A, Bustamante, M, Estivill, X, Gonzalez, JR, Llop, S, Kiess, W, Mahajan, A, Flexeder, C, Tiesler, CMT, Murray, CS, Simpson, A, Magnus, P, Sengpiel, V, Hartikainen, A, Keinanen-Kiukaanniemi, S, Lewin, A, Alves, ADSC, Blakemore, AI, Buxton, JL, Kaakinen, M, Rodriguez, A, Sebert, S, Vaarasmaki, M, Lakka, T, Lindi, V, Gehring, U, Postma, DS, Ang, W, Newnham, JP, Lyytikainen, L, Pahkala, K, Raitakari, OT, Panoutsopoulou, K, Zeggini, E, Boomsma, DI, Groen-Blokhuis, MM, Ilonen, J, Franke, L, Hirschhorn, JN, Pers, TH, Liang, L, Huang, J, Hocher, B, Knip, M, Saw, S, Holloway, JW, Melen, E, Grant, SFA, Feenstra, B, Lowe, WL, Widen, E, Sergeyev, E, Grallert, H, Custovic, A, Jacobsson, B, Jarvelin, M, Atalay, M, Koppelman, GH, Pennell, CE, Niinikoski, H, Dedoussis, GV, McCarthy, MI, Frayling, TM, Sunyer, J, Timpson, NJ, Rivadeneira, F, Bonnelykke, K & Jaddoe, VWV 2015, 'A novel common variant in DCST2 is associated with length in early life and height in adulthood', Human Molecular Genetics, vol. 24, no. 4, pp. 1155-1168. https://doi.org/10.1093/hmg/ddu510

TY - JOUR

T1 - A novel common variant in DCST2 is associated with length in early life and height in adulthood

AU - van der Valk, R.J.P.

AU - Kreiner-Moller, E.

AU - Kooijman, M.N.

AU - Guxens, M.

AU - Stergiakouli, E.

AU - Saaf, A.

AU - Bradfield, J.P.

AU - Geller, F.

AU - Hayes, M.G.

AU - Cousminer, D.L.

AU - Koerner, A.

AU - Thiering, E.

AU - Curtin, J.A.

AU - Myhre, R.

AU - Huikari, V.

AU - Joro, R.

AU - Kerkhof, M.

AU - Warrington, N.M.

AU - Pitkanen, N.

AU - Ntalla, I.

AU - Horikoshi, M.

AU - Veijola, R.

AU - Freathy, R.M.

AU - Teo, Y.

AU - Barton, S.J.

AU - Evans, D.M.

AU - Kemp, J.P.

AU - St Pourcain, B.

AU - Ring, S.M.

AU - Smith, G.D.

AU - Bergstrom, A.

AU - Kull, I.

AU - Hakonarson, H.

AU - Mentch, F.D.

AU - Bisgaard, H.

AU - Chawes, B.

AU - Stokholm, J.

AU - Waage, J.

AU - Eriksen, P.

AU - Sevelsted, A.

AU - Melbye, M.

AU - van Duijn, C.M.

AU - Medina-Gomez, C.

AU - Hofman, A.

AU - de Jongste, J.C.

AU - Taal, H.R.

AU - Uitterlinden, A. G.

AU - Armstrong, L.L.

AU - Eriksson, J.

AU - Palotie, A.

AU - Bustamante, M.

AU - Estivill, X.

AU - Gonzalez, J.R.

AU - Llop, S.

AU - Kiess, W.

AU - Mahajan, A.

AU - Flexeder, C.

AU - Tiesler, C.M.T.

AU - Murray, C.S.

AU - Simpson, A.

AU - Magnus, P.

AU - Sengpiel, V.

AU - Hartikainen, A.

AU - Keinanen-Kiukaanniemi, S.

AU - Lewin, A.

AU - Alves, A.D.S.C.

AU - Blakemore, A.I.

AU - Buxton, J.L.

AU - Kaakinen, M.

AU - Rodriguez, A.

AU - Sebert, S.

AU - Vaarasmaki, M.

AU - Lakka, T.

AU - Lindi, V.

AU - Gehring, U.

AU - Postma, D.S.

AU - Ang, W.

AU - Newnham, J.P.

AU - Lyytikainen, L.

AU - Pahkala, K.

AU - Raitakari, O.T.

AU - Panoutsopoulou, K.

AU - Zeggini, E.

AU - Boomsma, D.I.

AU - Groen-Blokhuis, M.M.

AU - Ilonen, J.

AU - Franke, L.

AU - Hirschhorn, J.N.

AU - Pers, T.H.

AU - Liang, L.

AU - Huang, J.

AU - Hocher, B.

AU - Knip, M.

AU - Saw, S.

AU - Holloway, J.W.

AU - Melen, E.

AU - Grant, S.F.A.

AU - Feenstra, B.

AU - Lowe, W.L.

AU - Widen, E.

AU - Sergeyev, E.

AU - Grallert, H.

AU - Custovic, A.

AU - Jacobsson, B.

AU - Jarvelin, M.

AU - Atalay, M.

AU - Koppelman, G.H.

AU - Pennell, C.E.

AU - Niinikoski, H.

AU - Dedoussis, G.V.

AU - McCarthy, M.I.

AU - Frayling, T.M.

AU - Sunyer, J.

AU - Timpson, N.J.

AU - Rivadeneira, F.

AU - Bonnelykke, K.

AU - Jaddoe, V.W.V.

N1 - PT: J; UT: WOS:000350138300021

PY - 2015

Y1 - 2015

N2 - Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10

AB - Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10

U2 - 10.1093/hmg/ddu510

DO - 10.1093/hmg/ddu510

M3 - Article

SN - 0964-6906

VL - 24

SP - 1155

EP - 1168

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 4

ER -

A novel common variant in DCST2 is associated with length in early life and height in adulthood

Abstract

Bibliographical note

Cohort Studies

Access to Document

Persistent URL (handle)

Fingerprint

Cite this