A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

M. Andaloussi, H.D. Lim, T.K. van der Meer, M. Sijm, C.B. Poulie, I.J.P. de Esch, R. Leurs, R.A. Smits

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

In this work we describe the optimization of a lead compound based on the quinazoline template to give a new series of potent pyrido[3,2-d]pyrimidines as histamine H
Original languageEnglish
Pages (from-to)2663-2670
JournalBioorganic and Medicinal Chemistry Letters
Volume2013
Issue number23
DOIs
Publication statusPublished - 2013

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