A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

M. Andaloussi; H.D. Lim; T.K. van der Meer; M. Sijm; C.B. Poulie; I.J.P. de Esch; R. Leurs; R.A. Smits

doi:10.1016/j.bmcl.2013.02.091

A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

M. Andaloussi, H.D. Lim, T.K. van der Meer, M. Sijm, C.B. Poulie, I.J.P. de Esch, R. Leurs, R.A. Smits

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

In this work we describe the optimization of a lead compound based on the quinazoline template to give a new series of potent pyrido[3,2-d]pyrimidines as histamine H

Original language	English
Pages (from-to)	2663-2670
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2013
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2013.02.091
Publication status	Published - 2013

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10.1016/j.bmcl.2013.02.091

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Andaloussi, M., Lim, H. D., van der Meer, T. K., Sijm, M., Poulie, C. B., de Esch, I. J. P., Leurs, R., & Smits, R. A. (2013). A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787. Bioorganic and Medicinal Chemistry Letters, 2013(23), 2663-2670. https://doi.org/10.1016/j.bmcl.2013.02.091

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title = "A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787",

abstract = "In this work we describe the optimization of a lead compound based on the quinazoline template to give a new series of potent pyrido[3,2-d]pyrimidines as histamine H",

author = "M. Andaloussi and H.D. Lim and {van der Meer}, T.K. and M. Sijm and C.B. Poulie and {de Esch}, I.J.P. and R. Leurs and R.A. Smits",

year = "2013",

doi = "10.1016/j.bmcl.2013.02.091",

language = "English",

volume = "2013",

pages = "2663--2670",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "23",

}

Andaloussi, M, Lim, HD, van der Meer, TK, Sijm, M, Poulie, CB, de Esch, IJP , Leurs, R & Smits, RA 2013, 'A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787', Bioorganic and Medicinal Chemistry Letters, vol. 2013, no. 23, pp. 2663-2670. https://doi.org/10.1016/j.bmcl.2013.02.091

A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787. / Andaloussi, M.; Lim, H.D.; van der Meer, T.K. et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 2013, No. 23, 2013, p. 2663-2670.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

AU - Andaloussi, M.

AU - Lim, H.D.

AU - van der Meer, T.K.

AU - Sijm, M.

AU - Poulie, C.B.

AU - de Esch, I.J.P.

AU - Leurs, R.

AU - Smits, R.A.

PY - 2013

Y1 - 2013

N2 - In this work we describe the optimization of a lead compound based on the quinazoline template to give a new series of potent pyrido[3,2-d]pyrimidines as histamine H

AB - In this work we describe the optimization of a lead compound based on the quinazoline template to give a new series of potent pyrido[3,2-d]pyrimidines as histamine H

U2 - 10.1016/j.bmcl.2013.02.091

DO - 10.1016/j.bmcl.2013.02.091

M3 - Article

SN - 0960-894X

VL - 2013

SP - 2663

EP - 2670

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

Abstract

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