A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

M. Andaloussi, H.D. Lim, T.K. van der Meer, M. Sijm, C.B. Poulie, I.J.P. de Esch, R. Leurs, R.A. Smits

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

In this work we describe the optimization of a lead compound based on the quinazoline template to give a new series of potent pyrido[3,2-d]pyrimidines as histamine H
Original languageEnglish
Pages (from-to)2663-2670
JournalBioorganic and Medicinal Chemistry Letters
Volume2013
Issue number23
DOIs
Publication statusPublished - 2013

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Quinazolines
Lead compounds
Histamine Receptors
Scaffolds
Histamine
PF-3893787
pyrido(3,2-d)pyrimidine
Lead

Cite this

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title = "A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787",
abstract = "In this work we describe the optimization of a lead compound based on the quinazoline template to give a new series of potent pyrido[3,2-d]pyrimidines as histamine H",
author = "M. Andaloussi and H.D. Lim and {van der Meer}, T.K. and M. Sijm and C.B. Poulie and {de Esch}, I.J.P. and R. Leurs and R.A. Smits",
year = "2013",
doi = "10.1016/j.bmcl.2013.02.091",
language = "English",
volume = "2013",
pages = "2663--2670",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "23",

}

A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787. / Andaloussi, M.; Lim, H.D.; van der Meer, T.K.; Sijm, M.; Poulie, C.B.; de Esch, I.J.P.; Leurs, R.; Smits, R.A.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 2013, No. 23, 2013, p. 2663-2670.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

AU - Andaloussi, M.

AU - Lim, H.D.

AU - van der Meer, T.K.

AU - Sijm, M.

AU - Poulie, C.B.

AU - de Esch, I.J.P.

AU - Leurs, R.

AU - Smits, R.A.

PY - 2013

Y1 - 2013

N2 - In this work we describe the optimization of a lead compound based on the quinazoline template to give a new series of potent pyrido[3,2-d]pyrimidines as histamine H

AB - In this work we describe the optimization of a lead compound based on the quinazoline template to give a new series of potent pyrido[3,2-d]pyrimidines as histamine H

U2 - 10.1016/j.bmcl.2013.02.091

DO - 10.1016/j.bmcl.2013.02.091

M3 - Article

VL - 2013

SP - 2663

EP - 2670

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 23

ER -