A Novel Three-Component Reaction toward Dihydrooxazolopyridines

R. Scheffelaar, M. Paravidino, D. Muilwijk, M. Lutz, A.L Spek, F.J.J. de Kanter, R.V.A. Orru, E. Ruijter

Research output: Contribution to JournalArticleAcademicpeer-review


Isocyano dihydropyridones accessible via a recently reported multicomponent reaction react with aldehydes and amines to afford dihydrooxazolopyridines in high yield. The scope and limitations of this novel multicomponent reaction were investigated. The efficient combination of two highly variable multicomponent reactions allows the construction of a very broad range of dihydrooxazolopyridines, an unexplored class of bicyclic compounds. The implications of the observed reactivity profile for the mechanism of this multicomponent reaction are discussed. © 2009 American Chemical Society.
Original languageEnglish
Pages (from-to)125-128
JournalOrganic letters
Issue number1
Publication statusPublished - 2009


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