A Novel Three-Component Reaction toward Dihydrooxazolopyridines

R. Scheffelaar, M. Paravidino, D. Muilwijk, M. Lutz, A.L Spek, F.J.J. de Kanter, R.V.A. Orru, E. Ruijter

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Isocyano dihydropyridones accessible via a recently reported multicomponent reaction react with aldehydes and amines to afford dihydrooxazolopyridines in high yield. The scope and limitations of this novel multicomponent reaction were investigated. The efficient combination of two highly variable multicomponent reactions allows the construction of a very broad range of dihydrooxazolopyridines, an unexplored class of bicyclic compounds. The implications of the observed reactivity profile for the mechanism of this multicomponent reaction are discussed. © 2009 American Chemical Society.
    Original languageEnglish
    Pages (from-to)125-128
    JournalOrganic letters
    Volume11
    Issue number1
    DOIs
    Publication statusPublished - 2009

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