A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease

P. Holmans; V. Moskvina; L. Jones; M. Sharma; A. Vedernikov; F. Buchel; M. Sadd; J.M. Bras; F. Bettella; N. Nicolaou; J. Simon Sanchez; F. Mittag; J.R. Gibbs; C. Schulte; A. Durr; R. Guerreiro; D. Hernandez; A. Brice; H. Stefánsson; K. Majamaa; T. Gasser; P. Heutink; N.W. Wood; M. Martinez; A.B. Singleton; M.A. Nalls; J. Hardy; H.R. Morris; N.M. Williams; Z. Bochdanovits

doi:10.1093/hmg/dds492

A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease

P. Holmans, V. Moskvina, L. Jones, M. Sharma, A. Vedernikov, F. Buchel, M. Sadd, J.M. Bras, F. Bettella, N. Nicolaou, J. Simon Sanchez, F. Mittag, J.R. Gibbs, C. Schulte, A. Durr, R. Guerreiro, D. Hernandez, A. Brice, H. Stefánsson, K. MajamaaT. Gasser, P. Heutink, N.W. Wood, M. Martinez, A.B. Singleton, M.A. Nalls, J. Hardy, H.R. Morris, N.M. Williams, Z. Bochdanovits

Functional Genomics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease affecting 1-2% in people >60 and 3-4% in people >80. Genome-wide association (GWA) studies have now implicated significant evidence for association in at least 18 genomic regions. We have studied a large PD-meta analysis and identified a significant excess of SNPs (P < 1 × 10

Original language	English
Pages (from-to)	1039-1049
Journal	Human Molecular Genetics
Volume	22
Issue number	5
DOIs	https://doi.org/10.1093/hmg/dds492
Publication status	Published - 2013

Bibliographical note

International Parkinson's Disease Genomics Consortium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Holmans, P., Moskvina, V., Jones, L., Sharma, M., Vedernikov, A., Buchel, F., Sadd, M., Bras, J. M., Bettella, F., Nicolaou, N., Simon Sanchez, J., Mittag, F., Gibbs, J. R., Schulte, C., Durr, A., Guerreiro, R., Hernandez, D., Brice, A., Stefánsson, H., ... Bochdanovits, Z. (2013). A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Human Molecular Genetics, 22(5), 1039-1049. https://doi.org/10.1093/hmg/dds492

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title = "A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease",

abstract = "Parkinson's disease (PD) is the second most common neurodegenerative disease affecting 1-2% in people >60 and 3-4% in people >80. Genome-wide association (GWA) studies have now implicated significant evidence for association in at least 18 genomic regions. We have studied a large PD-meta analysis and identified a significant excess of SNPs (P < 1 × 10",

author = "P. Holmans and V. Moskvina and L. Jones and M. Sharma and A. Vedernikov and F. Buchel and M. Sadd and J.M. Bras and F. Bettella and N. Nicolaou and {Simon Sanchez}, J. and F. Mittag and J.R. Gibbs and C. Schulte and A. Durr and R. Guerreiro and D. Hernandez and A. Brice and H. Stef{\'a}nsson and K. Majamaa and T. Gasser and P. Heutink and N.W. Wood and M. Martinez and A.B. Singleton and M.A. Nalls and J. Hardy and H.R. Morris and N.M. Williams and Z. Bochdanovits",

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Holmans, P, Moskvina, V, Jones, L, Sharma, M, Vedernikov, A, Buchel, F, Sadd, M, Bras, JM, Bettella, F, Nicolaou, N, Simon Sanchez, J, Mittag, F, Gibbs, JR, Schulte, C, Durr, A, Guerreiro, R, Hernandez, D, Brice, A, Stefánsson, H, Majamaa, K, Gasser, T, Heutink, P, Wood, NW, Martinez, M, Singleton, AB, Nalls, MA, Hardy, J, Morris, HR, Williams, NM & Bochdanovits, Z 2013, 'A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease', Human Molecular Genetics, vol. 22, no. 5, pp. 1039-1049. https://doi.org/10.1093/hmg/dds492

TY - JOUR

T1 - A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease

AU - Holmans, P.

AU - Moskvina, V.

AU - Jones, L.

AU - Sharma, M.

AU - Vedernikov, A.

AU - Buchel, F.

AU - Sadd, M.

AU - Bras, J.M.

AU - Bettella, F.

AU - Nicolaou, N.

AU - Simon Sanchez, J.

AU - Mittag, F.

AU - Gibbs, J.R.

AU - Schulte, C.

AU - Durr, A.

AU - Guerreiro, R.

AU - Hernandez, D.

AU - Brice, A.

AU - Stefánsson, H.

AU - Majamaa, K.

AU - Gasser, T.

AU - Heutink, P.

AU - Wood, N.W.

AU - Martinez, M.

AU - Singleton, A.B.

AU - Nalls, M.A.

AU - Hardy, J.

AU - Morris, H.R.

AU - Williams, N.M.

AU - Bochdanovits, Z.

N1 - International Parkinson's Disease Genomics Consortium

PY - 2013

Y1 - 2013

N2 - Parkinson's disease (PD) is the second most common neurodegenerative disease affecting 1-2% in people >60 and 3-4% in people >80. Genome-wide association (GWA) studies have now implicated significant evidence for association in at least 18 genomic regions. We have studied a large PD-meta analysis and identified a significant excess of SNPs (P < 1 × 10

AB - Parkinson's disease (PD) is the second most common neurodegenerative disease affecting 1-2% in people >60 and 3-4% in people >80. Genome-wide association (GWA) studies have now implicated significant evidence for association in at least 18 genomic regions. We have studied a large PD-meta analysis and identified a significant excess of SNPs (P < 1 × 10

U2 - 10.1093/hmg/dds492

DO - 10.1093/hmg/dds492

M3 - Article

SN - 0964-6906

VL - 22

SP - 1039

EP - 1049

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 5

ER -

A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease

Abstract

Bibliographical note

UN SDGs

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