A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer.

J.A. Langendijk, P.A.H. Doornaert, D.H.F. Rietveld, I.M. de Leeuw, C.R. Leemans, B.J. Slotman

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Introduction: Recently, we found that swallowing dysfunction after curative (chemo) radiation (CH) RT has a strong negative impact on health-related quality of life (HRQoL), even more than xerostomia. The purpose of this study was to design a predictive model for swallowing dysfunction after curative radiotherapy or chemoradiation. Materials and methods: A prospective study was performed including 529 patients with head and neck squamous cell carcinoma (HNSCC) treated with curative (CH) RT. In all patients, acute and late radiation-induced morbidity (RTOG Acute and Late Morbidity Scoring System) was scored prospectively. To design the model univariate and multivariate logistic regression analyses were carried out with grade 2 or higher RTOG swallowing dysfunction at 6 months as the primary (SWALL
Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalRadiotherapy and Oncology
Volume90
Issue number2
DOIs
Publication statusPublished - 2009

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