Abstract
Objective: The study evaluated the efficacy of phototherapy and 20% albumin infusion to reduce total serum bilirubin (TSB) in neonates with severe hyperbilirubinemia. The primary outcome was a reduction of TSB at the end of treatment. The secondary outcomes were the need for exchange transfusion, inpatient mortality, neurological outcomes at discharge, and development outcomes at 12-months follow-up. Results: One hundred and eighteen neonates were randomly assigned to phototherapy and 20% albumin (n = 59) and phototherapy and saline (n = 69). The median age at admission was 5 (interquartile range (IQR) 3-6) days, and the median gestation was 36 (IQR 36-38) weeks. No significant differences were found in the change in TSB (Mann-Whitney U =609, p = 0.98) and rate of change in TSB per hour after treatment (Mann-Whitney U = 540, p = 0.39) between the two groups. There were no significant differences between the two groups in the proportion of participants who required exchange transfusion (χ2 (2) = 0.36, p = 0.546); repeat phototherapy (χ2 (2) = 2.37, p = 0.123); and those who died (χ2 (2) = 0.92, p = 0.337). Trial registration The trial was registered in the International Standardized Randomized Controlled Trial Number (ISRCTN); trial registration number ISRCTN89732754.
| Original language | English |
|---|---|
| Article number | 617 |
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | BMC Research Notes |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 23 Sep 2019 |
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Keywords
- Albumin
- Neonatal jaundice
- Neonates
- Saline
- Sub-Saharan Africa
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A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya. / Magai, Dorcas N.; Mwaniki, Michael; Abubakar, Amina; Mohammed, Shebe; Gordon, Anne L.; Kalu, Raphael; Mwangi, Paul; Koot, Hans M.; Newton, Charles R.
In: BMC Research Notes, Vol. 12, No. 1, 617, 23.09.2019, p. 1-6.Research output: Contribution to Journal › Article › Academic › peer-review
TY - JOUR
T1 - A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya
AU - Magai, Dorcas N.
AU - Mwaniki, Michael
AU - Abubakar, Amina
AU - Mohammed, Shebe
AU - Gordon, Anne L.
AU - Kalu, Raphael
AU - Mwangi, Paul
AU - Koot, Hans M.
AU - Newton, Charles R.
PY - 2019/9/23
Y1 - 2019/9/23
N2 - Objective: The study evaluated the efficacy of phototherapy and 20% albumin infusion to reduce total serum bilirubin (TSB) in neonates with severe hyperbilirubinemia. The primary outcome was a reduction of TSB at the end of treatment. The secondary outcomes were the need for exchange transfusion, inpatient mortality, neurological outcomes at discharge, and development outcomes at 12-months follow-up. Results: One hundred and eighteen neonates were randomly assigned to phototherapy and 20% albumin (n = 59) and phototherapy and saline (n = 69). The median age at admission was 5 (interquartile range (IQR) 3-6) days, and the median gestation was 36 (IQR 36-38) weeks. No significant differences were found in the change in TSB (Mann-Whitney U =609, p = 0.98) and rate of change in TSB per hour after treatment (Mann-Whitney U = 540, p = 0.39) between the two groups. There were no significant differences between the two groups in the proportion of participants who required exchange transfusion (χ2 (2) = 0.36, p = 0.546); repeat phototherapy (χ2 (2) = 2.37, p = 0.123); and those who died (χ2 (2) = 0.92, p = 0.337). Trial registration The trial was registered in the International Standardized Randomized Controlled Trial Number (ISRCTN); trial registration number ISRCTN89732754.
AB - Objective: The study evaluated the efficacy of phototherapy and 20% albumin infusion to reduce total serum bilirubin (TSB) in neonates with severe hyperbilirubinemia. The primary outcome was a reduction of TSB at the end of treatment. The secondary outcomes were the need for exchange transfusion, inpatient mortality, neurological outcomes at discharge, and development outcomes at 12-months follow-up. Results: One hundred and eighteen neonates were randomly assigned to phototherapy and 20% albumin (n = 59) and phototherapy and saline (n = 69). The median age at admission was 5 (interquartile range (IQR) 3-6) days, and the median gestation was 36 (IQR 36-38) weeks. No significant differences were found in the change in TSB (Mann-Whitney U =609, p = 0.98) and rate of change in TSB per hour after treatment (Mann-Whitney U = 540, p = 0.39) between the two groups. There were no significant differences between the two groups in the proportion of participants who required exchange transfusion (χ2 (2) = 0.36, p = 0.546); repeat phototherapy (χ2 (2) = 2.37, p = 0.123); and those who died (χ2 (2) = 0.92, p = 0.337). Trial registration The trial was registered in the International Standardized Randomized Controlled Trial Number (ISRCTN); trial registration number ISRCTN89732754.
KW - Albumin
KW - Neonatal jaundice
KW - Neonates
KW - Saline
KW - Sub-Saharan Africa
UR - http://www.scopus.com/inward/record.url?scp=85072571100&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072571100&partnerID=8YFLogxK
U2 - 10.1186/s13104-019-4632-2
DO - 10.1186/s13104-019-4632-2
M3 - Article
VL - 12
SP - 1
EP - 6
JO - BMC Research Notes
JF - BMC Research Notes
SN - 1756-0500
IS - 1
M1 - 617
ER -