@article{9cb62cfd4f914c17b641b3958f83d0c0,
title = "A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya",
abstract = "Objective: The study evaluated the efficacy of phototherapy and 20% albumin infusion to reduce total serum bilirubin (TSB) in neonates with severe hyperbilirubinemia. The primary outcome was a reduction of TSB at the end of treatment. The secondary outcomes were the need for exchange transfusion, inpatient mortality, neurological outcomes at discharge, and development outcomes at 12-months follow-up. Results: One hundred and eighteen neonates were randomly assigned to phototherapy and 20% albumin (n = 59) and phototherapy and saline (n = 69). The median age at admission was 5 (interquartile range (IQR) 3-6) days, and the median gestation was 36 (IQR 36-38) weeks. No significant differences were found in the change in TSB (Mann-Whitney U =609, p = 0.98) and rate of change in TSB per hour after treatment (Mann-Whitney U = 540, p = 0.39) between the two groups. There were no significant differences between the two groups in the proportion of participants who required exchange transfusion (χ2 (2) = 0.36, p = 0.546); repeat phototherapy (χ2 (2) = 2.37, p = 0.123); and those who died (χ2 (2) = 0.92, p = 0.337). Trial registration The trial was registered in the International Standardized Randomized Controlled Trial Number (ISRCTN); trial registration number ISRCTN89732754.",
keywords = "Albumin, Neonatal jaundice, Neonates, Saline, Sub-Saharan Africa",
author = "Magai, {Dorcas N.} and Michael Mwaniki and Amina Abubakar and Shebe Mohammed and Gordon, {Anne L.} and Raphael Kalu and Paul Mwangi and Koot, {Hans M.} and Newton, {Charles R.}",
year = "2019",
month = sep,
day = "23",
doi = "10.1186/s13104-019-4632-2",
language = "English",
volume = "12",
pages = "1--6",
journal = "BMC Research Notes",
issn = "1756-0500",
publisher = "BioMed Central",
number = "1",
}