A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya

Dorcas N. Magai, Michael Mwaniki, Amina Abubakar, Shebe Mohammed, Anne L. Gordon, Raphael Kalu, Paul Mwangi, Hans M. Koot, Charles R. Newton

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objective: The study evaluated the efficacy of phototherapy and 20% albumin infusion to reduce total serum bilirubin (TSB) in neonates with severe hyperbilirubinemia. The primary outcome was a reduction of TSB at the end of treatment. The secondary outcomes were the need for exchange transfusion, inpatient mortality, neurological outcomes at discharge, and development outcomes at 12-months follow-up. Results: One hundred and eighteen neonates were randomly assigned to phototherapy and 20% albumin (n = 59) and phototherapy and saline (n = 69). The median age at admission was 5 (interquartile range (IQR) 3-6) days, and the median gestation was 36 (IQR 36-38) weeks. No significant differences were found in the change in TSB (Mann-Whitney U =609, p = 0.98) and rate of change in TSB per hour after treatment (Mann-Whitney U = 540, p = 0.39) between the two groups. There were no significant differences between the two groups in the proportion of participants who required exchange transfusion (χ2 (2) = 0.36, p = 0.546); repeat phototherapy (χ2 (2) = 2.37, p = 0.123); and those who died (χ2 (2) = 0.92, p = 0.337). Trial registration The trial was registered in the International Standardized Randomized Controlled Trial Number (ISRCTN); trial registration number ISRCTN89732754.

Original languageEnglish
Article number617
Pages (from-to)1-6
Number of pages6
JournalBMC Research Notes
Volume12
Issue number1
DOIs
Publication statusPublished - 23 Sep 2019

Fingerprint

Phototherapy
Kenya
Bilirubin
Albumins
Serum
Newborn Infant
Hyperbilirubinemia
Inpatients
Randomized Controlled Trials
Pregnancy
Mortality
Therapeutics

Keywords

  • Albumin
  • Neonatal jaundice
  • Neonates
  • Saline
  • Sub-Saharan Africa

Cite this

Magai, Dorcas N. ; Mwaniki, Michael ; Abubakar, Amina ; Mohammed, Shebe ; Gordon, Anne L. ; Kalu, Raphael ; Mwangi, Paul ; Koot, Hans M. ; Newton, Charles R. / A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya. In: BMC Research Notes. 2019 ; Vol. 12, No. 1. pp. 1-6.
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Magai, DN, Mwaniki, M, Abubakar, A, Mohammed, S, Gordon, AL, Kalu, R, Mwangi, P, Koot, HM & Newton, CR 2019, 'A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya' BMC Research Notes, vol. 12, no. 1, 617, pp. 1-6. https://doi.org/10.1186/s13104-019-4632-2

A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya. / Magai, Dorcas N.; Mwaniki, Michael; Abubakar, Amina; Mohammed, Shebe; Gordon, Anne L.; Kalu, Raphael; Mwangi, Paul; Koot, Hans M.; Newton, Charles R.

In: BMC Research Notes, Vol. 12, No. 1, 617, 23.09.2019, p. 1-6.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Mwaniki, Michael

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