A reason for intermittent fasting to suppress the awakening of dormant breast tumors.

J. Lankelma, B.W. Kooi, K. Krab, J.C. Dorsman, H. Joenje, H.V. Westerhoff

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

For their growth, dormant tumors, which lack angiogenesis may critically depend on gradients of nutrients and oxygen from the nearest blood vessel. Because for oxygen depletion the distance from the nearest blood vessel to depletion will generally be shorter than for glucose depletion, such tumors will contain anoxic living tumor cells. These cells are dangerous, because they are capable of inducing angiogenesis, which will "wake up" the tumor. Anoxic cells are dependent on anaerobic glucose breakdown for ATP generation. The local extracellular glucose concentration gradient is determined by the blood glucose concentration and by consumption by cells closer to the nearest blood vessel. The blood glucose concentration can be lowered by 20-40% during fasting. We calculated that glucose supply to the potentially hazardous anoxic cells can thereby be reduced significantly, resulting in cell death specifically of the anoxic tumor cells. We hypothesize that intermittent fasting will help to reduce the incidence of tumor relapse via reducing the number of anoxic tumor cells and tumor awakening.
Original languageEnglish
Pages (from-to)1-6
JournalBioSystems
Volume127
DOIs
Publication statusPublished - 2015

Fingerprint

Tumors
Tumor
Fasting
Glucose
Breast Neoplasms
Cell
Blood Vessels
Neoplasms
Blood vessels
Depletion
Angiogenesis
Cells
Blood
Blood Glucose
Oxygen
Gradient
Tumor Growth
Adenosinetriphosphate
Cell death
Nutrients

Cite this

@article{e36ba92867d0431f893e3ddcb28f5a3c,
title = "A reason for intermittent fasting to suppress the awakening of dormant breast tumors.",
abstract = "For their growth, dormant tumors, which lack angiogenesis may critically depend on gradients of nutrients and oxygen from the nearest blood vessel. Because for oxygen depletion the distance from the nearest blood vessel to depletion will generally be shorter than for glucose depletion, such tumors will contain anoxic living tumor cells. These cells are dangerous, because they are capable of inducing angiogenesis, which will {"}wake up{"} the tumor. Anoxic cells are dependent on anaerobic glucose breakdown for ATP generation. The local extracellular glucose concentration gradient is determined by the blood glucose concentration and by consumption by cells closer to the nearest blood vessel. The blood glucose concentration can be lowered by 20-40{\%} during fasting. We calculated that glucose supply to the potentially hazardous anoxic cells can thereby be reduced significantly, resulting in cell death specifically of the anoxic tumor cells. We hypothesize that intermittent fasting will help to reduce the incidence of tumor relapse via reducing the number of anoxic tumor cells and tumor awakening.",
author = "J. Lankelma and B.W. Kooi and K. Krab and J.C. Dorsman and H. Joenje and H.V. Westerhoff",
year = "2015",
doi = "10.1016/j.biosystems.2014.11.001",
language = "English",
volume = "127",
pages = "1--6",
journal = "BioSystems",
issn = "0303-2647",
publisher = "Elsevier Ireland Ltd",

}

A reason for intermittent fasting to suppress the awakening of dormant breast tumors. / Lankelma, J.; Kooi, B.W.; Krab, K.; Dorsman, J.C.; Joenje, H.; Westerhoff, H.V.

In: BioSystems, Vol. 127, 2015, p. 1-6.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - A reason for intermittent fasting to suppress the awakening of dormant breast tumors.

AU - Lankelma, J.

AU - Kooi, B.W.

AU - Krab, K.

AU - Dorsman, J.C.

AU - Joenje, H.

AU - Westerhoff, H.V.

PY - 2015

Y1 - 2015

N2 - For their growth, dormant tumors, which lack angiogenesis may critically depend on gradients of nutrients and oxygen from the nearest blood vessel. Because for oxygen depletion the distance from the nearest blood vessel to depletion will generally be shorter than for glucose depletion, such tumors will contain anoxic living tumor cells. These cells are dangerous, because they are capable of inducing angiogenesis, which will "wake up" the tumor. Anoxic cells are dependent on anaerobic glucose breakdown for ATP generation. The local extracellular glucose concentration gradient is determined by the blood glucose concentration and by consumption by cells closer to the nearest blood vessel. The blood glucose concentration can be lowered by 20-40% during fasting. We calculated that glucose supply to the potentially hazardous anoxic cells can thereby be reduced significantly, resulting in cell death specifically of the anoxic tumor cells. We hypothesize that intermittent fasting will help to reduce the incidence of tumor relapse via reducing the number of anoxic tumor cells and tumor awakening.

AB - For their growth, dormant tumors, which lack angiogenesis may critically depend on gradients of nutrients and oxygen from the nearest blood vessel. Because for oxygen depletion the distance from the nearest blood vessel to depletion will generally be shorter than for glucose depletion, such tumors will contain anoxic living tumor cells. These cells are dangerous, because they are capable of inducing angiogenesis, which will "wake up" the tumor. Anoxic cells are dependent on anaerobic glucose breakdown for ATP generation. The local extracellular glucose concentration gradient is determined by the blood glucose concentration and by consumption by cells closer to the nearest blood vessel. The blood glucose concentration can be lowered by 20-40% during fasting. We calculated that glucose supply to the potentially hazardous anoxic cells can thereby be reduced significantly, resulting in cell death specifically of the anoxic tumor cells. We hypothesize that intermittent fasting will help to reduce the incidence of tumor relapse via reducing the number of anoxic tumor cells and tumor awakening.

U2 - 10.1016/j.biosystems.2014.11.001

DO - 10.1016/j.biosystems.2014.11.001

M3 - Article

VL - 127

SP - 1

EP - 6

JO - BioSystems

JF - BioSystems

SN - 0303-2647

ER -