A refined substrate model for human cytochrome P450 2D6.

M.J. de Groot, G.J. Bijlo, B.J. Martens, F.A.A. van Acker, N.P.E. Vermeulen

Research output: Contribution to JournalArticleAcademicpeer-review


Cytochromes P450 (P450s) constitute a large superfamily of heme- containing enzymes, capable of oxidizing and reducing a variety of substrates. Cytochrome P450 2D6 is a polymorphic member of the P450 superfamily and is absent in 5-9% of the Caucasian population as a result of a recessive inheritance of gene mutations. Recently, the importance of aspartic acid 301 (Asp
Original languageEnglish
Pages (from-to)41-48
JournalChemical Research in Toxicology
Publication statusPublished - 1997


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