A refined substrate model for human cytochrome P450 2D6.

M.J. de Groot; G.J. Bijlo; B.J. Martens; F.A.A. van Acker; N.P.E. Vermeulen

doi:10.1021/tx960129f

A refined substrate model for human cytochrome P450 2D6.

M.J. de Groot
, G.J. Bijlo
, B.J. Martens
, F.A.A. van Acker
, N.P.E. Vermeulen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Cytochromes P450 (P450s) constitute a large superfamily of heme- containing enzymes, capable of oxidizing and reducing a variety of substrates. Cytochrome P450 2D6 is a polymorphic member of the P450 superfamily and is absent in 5-9% of the Caucasian population as a result of a recessive inheritance of gene mutations. Recently, the importance of aspartic acid 301 (Asp

Original language	English
Pages (from-to)	41-48
Journal	Chemical Research in Toxicology
Volume	10
DOIs	https://doi.org/10.1021/tx960129f
Publication status	Published - 1997

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title = "A refined substrate model for human cytochrome P450 2D6.",

abstract = "Cytochromes P450 (P450s) constitute a large superfamily of heme- containing enzymes, capable of oxidizing and reducing a variety of substrates. Cytochrome P450 2D6 is a polymorphic member of the P450 superfamily and is absent in 5-9\% of the Caucasian population as a result of a recessive inheritance of gene mutations. Recently, the importance of aspartic acid 301 (Asp",

author = "\{de Groot\}, M.J. and G.J. Bijlo and B.J. Martens and \{van Acker\}, F.A.A. and N.P.E. Vermeulen",

year = "1997",

doi = "10.1021/tx960129f",

language = "English",

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journal = "Chemical Research in Toxicology",

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AU - de Groot, M.J.

AU - Bijlo, G.J.

AU - Martens, B.J.

AU - van Acker, F.A.A.

AU - Vermeulen, N.P.E.

PY - 1997

Y1 - 1997

N2 - Cytochromes P450 (P450s) constitute a large superfamily of heme- containing enzymes, capable of oxidizing and reducing a variety of substrates. Cytochrome P450 2D6 is a polymorphic member of the P450 superfamily and is absent in 5-9% of the Caucasian population as a result of a recessive inheritance of gene mutations. Recently, the importance of aspartic acid 301 (Asp

AB - Cytochromes P450 (P450s) constitute a large superfamily of heme- containing enzymes, capable of oxidizing and reducing a variety of substrates. Cytochrome P450 2D6 is a polymorphic member of the P450 superfamily and is absent in 5-9% of the Caucasian population as a result of a recessive inheritance of gene mutations. Recently, the importance of aspartic acid 301 (Asp

U2 - 10.1021/tx960129f

DO - 10.1021/tx960129f

M3 - Article

SN - 0893-228X

VL - 10

SP - 41

EP - 48

JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

ER -

A refined substrate model for human cytochrome P450 2D6.

Abstract

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