A research agenda to reinforce rabies control: A qualitative and quantitative prioritization

Anne M.G. Neevel*, Tessa Hemrika, Eric Claassen, Linda H.M. van de Burgwal

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


Background: Despite the existence of safe and effective vaccines, rabies disease still causes an estimated 59,000 human deaths a year in the endemic areas in Asia and Africa. These numbers reflect severe drawbacks regarding the implementation of PrEP and PEP in endemic settings, such as lack of political will and low priority given to rabies. Since these contextual factors have proven to be persistent, there is an urgency to improve current strategies or develop novel approaches in order to control rabies disease in the future. Methods/Findings: This study aimed to identify and systematically prioritize the research needs, through interviews and questionnaires with key-opinion-leaders (KOLs). A total of 46 research needs were identified and prioritized. The top research needs are considered very high priority based on both importance for rabies control and need for improvement. KOLs agree that animal rabies control remains most important for rabies control, while research on human host, agent (rabies virus) and the environment should be prioritized in terms of need for improvement. A wide variety in perceptions is observed between and within the disciplines of virology, public health and veterinary health and between KOLs with more versus those with less experience in the field. Conclusion/Significance: The results of this study give well-defined, prioritized issues that stress the drawbacks that are experienced by KOLs in daily practice. The most important research domains are: 1) cheap and scalable production system for RIG 2) efficacy of dog mass vaccination programs and 3) cheap human vaccines. Addressing these research needs should exist next to and may reinforce current awareness and mass vaccination campaigns. The differences in perspectives between actors revealed in this study are informative for effective execution of the One Health research agenda.

Original languageEnglish
Article numbere0006387
JournalPLoS Neglected Tropical Diseases
Issue number5
Publication statusPublished - 4 May 2018


EC received funding from the European Community’s Seventh Framework Programme under grant agreement No.602825-2 (Project ASKLEPIOS). Funder's website: https://ec.europa.eu/research/fp7/index_en.cfm. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors gratefully acknowledge the contribution of all participants of the interviews.

FundersFunder number
Seventh Framework Programme602825
Erzincan ÜniversitesiFP7 602825


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