A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic

K. Svokos; J.B. Nalwalk; R. Leurs; W.M.P.B. Menge; H. Timmerman; L.H. Hough

doi:10.1016/S0006-8993(01)03191-2

A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic

K. Svokos
, J.B. Nalwalk
, R. Leurs
, W.M.P.B. Menge
, H. Timmerman
, L.H. Hough

Chemistry and Pharmaceutical Sciences

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Improgan is a derivative of cimetidine that induces non-opioid antinociception after intracerebroventricular (i.c.v.) administration, but the mechanism of action of this compound remains unknown. Since activation of either supraspinal or spinal α

Original language	English
Pages (from-to)	12-9
Journal	Brain Research
Volume	923
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(01)03191-2
Publication status	Published - 2001

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/S0006-8993(01)03191-2

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title = "A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic",

abstract = "Improgan is a derivative of cimetidine that induces non-opioid antinociception after intracerebroventricular (i.c.v.) administration, but the mechanism of action of this compound remains unknown. Since activation of either supraspinal or spinal α",

author = "K. Svokos and J.B. Nalwalk and R. Leurs and W.M.P.B. Menge and H. Timmerman and L.H. Hough",

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AU - Svokos, K.

AU - Nalwalk, J.B.

AU - Leurs, R.

AU - Menge, W.M.P.B.

AU - Timmerman, H.

AU - Hough, L.H.

PY - 2001

Y1 - 2001

N2 - Improgan is a derivative of cimetidine that induces non-opioid antinociception after intracerebroventricular (i.c.v.) administration, but the mechanism of action of this compound remains unknown. Since activation of either supraspinal or spinal α

AB - Improgan is a derivative of cimetidine that induces non-opioid antinociception after intracerebroventricular (i.c.v.) administration, but the mechanism of action of this compound remains unknown. Since activation of either supraspinal or spinal α

U2 - 10.1016/S0006-8993(01)03191-2

DO - 10.1016/S0006-8993(01)03191-2

M3 - Article

SN - 0006-8993

VL - 923

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EP - 19

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic

Abstract

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