A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells

J. Zenker, M. Stettner, S. Ruskamo, E. Domenech-Estevez, H. Baloui, J.J. Medard, M.H.G. Verheijen, J.F. Brouwers, P. Kursula, B.C. Kieseier, R. Chrast

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Peripheral myelin protein 2 (Pmp2, P2 or Fabp8), a member of the fatty acid binding protein family, was originally described together with myelin basic protein (Mbp or P1) and myelin protein zero (Mpz or P0) as one of the most abundant myelin proteins in the peripheral nervous system (PNS). Although Pmp2 is predominantly expressed in myelinated Schwann cells, its role in glia is currently unknown. To study its function in PNS biology, we have generated a complete Pmp2 knockout mouse (Pmp2
Original languageEnglish
Pages (from-to)1502-1512
JournalGlia
Volume62
Issue number9
DOIs
Publication statusPublished - 2014

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