A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells

J. Zenker; M. Stettner; S. Ruskamo; E. Domenech-Estevez; H. Baloui; J.J. Medard; M.H.G. Verheijen; J.F. Brouwers; P. Kursula; B.C. Kieseier; R. Chrast

doi:10.1002/glia.22696

A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells

J. Zenker, M. Stettner, S. Ruskamo, E. Domenech-Estevez, H. Baloui, J.J. Medard, M.H.G. Verheijen, J.F. Brouwers, P. Kursula, B.C. Kieseier, R. Chrast

Molecular and Cellular Neurobiology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Peripheral myelin protein 2 (Pmp2, P2 or Fabp8), a member of the fatty acid binding protein family, was originally described together with myelin basic protein (Mbp or P1) and myelin protein zero (Mpz or P0) as one of the most abundant myelin proteins in the peripheral nervous system (PNS). Although Pmp2 is predominantly expressed in myelinated Schwann cells, its role in glia is currently unknown. To study its function in PNS biology, we have generated a complete Pmp2 knockout mouse (Pmp2

Original language	English
Pages (from-to)	1502-1512
Journal	Glia
Volume	62
Issue number	9
DOIs	https://doi.org/10.1002/glia.22696
Publication status	Published - 2014

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10.1002/glia.22696

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title = "A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells",

abstract = "Peripheral myelin protein 2 (Pmp2, P2 or Fabp8), a member of the fatty acid binding protein family, was originally described together with myelin basic protein (Mbp or P1) and myelin protein zero (Mpz or P0) as one of the most abundant myelin proteins in the peripheral nervous system (PNS). Although Pmp2 is predominantly expressed in myelinated Schwann cells, its role in glia is currently unknown. To study its function in PNS biology, we have generated a complete Pmp2 knockout mouse (Pmp2",

author = "J. Zenker and M. Stettner and S. Ruskamo and E. Domenech-Estevez and H. Baloui and J.J. Medard and M.H.G. Verheijen and J.F. Brouwers and P. Kursula and B.C. Kieseier and R. Chrast",

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T1 - A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells

AU - Zenker, J.

AU - Stettner, M.

AU - Ruskamo, S.

AU - Domenech-Estevez, E.

AU - Baloui, H.

AU - Medard, J.J.

AU - Verheijen, M.H.G.

AU - Brouwers, J.F.

AU - Kursula, P.

AU - Kieseier, B.C.

AU - Chrast, R.

PY - 2014

Y1 - 2014

N2 - Peripheral myelin protein 2 (Pmp2, P2 or Fabp8), a member of the fatty acid binding protein family, was originally described together with myelin basic protein (Mbp or P1) and myelin protein zero (Mpz or P0) as one of the most abundant myelin proteins in the peripheral nervous system (PNS). Although Pmp2 is predominantly expressed in myelinated Schwann cells, its role in glia is currently unknown. To study its function in PNS biology, we have generated a complete Pmp2 knockout mouse (Pmp2

AB - Peripheral myelin protein 2 (Pmp2, P2 or Fabp8), a member of the fatty acid binding protein family, was originally described together with myelin basic protein (Mbp or P1) and myelin protein zero (Mpz or P0) as one of the most abundant myelin proteins in the peripheral nervous system (PNS). Although Pmp2 is predominantly expressed in myelinated Schwann cells, its role in glia is currently unknown. To study its function in PNS biology, we have generated a complete Pmp2 knockout mouse (Pmp2

U2 - 10.1002/glia.22696

DO - 10.1002/glia.22696

M3 - Article

SN - 0894-1491

VL - 62

SP - 1502

EP - 1512

JO - Glia

JF - Glia

IS - 9

ER -

A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells

Abstract

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