A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine

T. Hashimoto; S. Harusawa; L. Araki; O.P. Zuiderveld; M.J. Smit; T. Imazu; S. Takashima; Y. Yamamoto; Y. Sakamoto; T. Kurihara; R. Leurs; R.A. Bakker; A. Yamatodani

doi:10.1021/jm0300025

A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine

T. Hashimoto, S. Harusawa, L. Araki, O.P. Zuiderveld, M.J. Smit, T. Imazu, S. Takashima, Y. Yamamoto, Y. Sakamoto, T. Kurihara, R. Leurs, R.A. Bakker, A. Yamatodani

Medicinal chemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A series of 16 compounds related to chiral 4(5)-(5-aminomethyltetrahydrofuran-2-yl)imidazoles (1) have been designed, synthesized, and examined in vitro by radioligand displacement studies and functional assays for both the human H

Original language	English
Pages (from-to)	3162-5
Journal	Journal of Medicinal Chemistry
Volume	46
Issue number	14
DOIs	https://doi.org/10.1021/jm0300025
Publication status	Published - 2003

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Hashimoto, T., Harusawa, S., Araki, L., Zuiderveld, O. P., Smit, M. J., Imazu, T., Takashima, S., Yamamoto, Y., Sakamoto, Y., Kurihara, T., Leurs, R., Bakker, R. A., & Yamatodani, A. (2003). A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine. Journal of Medicinal Chemistry, 46(14), 3162-5. https://doi.org/10.1021/jm0300025

Hashimoto, T. ; Harusawa, S. ; Araki, L. ; Zuiderveld, O.P. ; Smit, M.J. ; Imazu, T. ; Takashima, S. ; Yamamoto, Y. ; Sakamoto, Y. ; Kurihara, T. ; Leurs, R. ; Bakker, R.A. ; Yamatodani, A. / A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine. In: Journal of Medicinal Chemistry. 2003 ; Vol. 46, No. 14. pp. 3162-5.

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title = "A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine",

abstract = "A series of 16 compounds related to chiral 4(5)-(5-aminomethyltetrahydrofuran-2-yl)imidazoles (1) have been designed, synthesized, and examined in vitro by radioligand displacement studies and functional assays for both the human H",

author = "T. Hashimoto and S. Harusawa and L. Araki and O.P. Zuiderveld and M.J. Smit and T. Imazu and S. Takashima and Y. Yamamoto and Y. Sakamoto and T. Kurihara and R. Leurs and R.A. Bakker and A. Yamatodani",

year = "2003",

doi = "10.1021/jm0300025",

language = "English",

volume = "46",

pages = "3162--5",

journal = "Journal of Medicinal Chemistry",

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publisher = "American Chemical Society",

number = "14",

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Hashimoto, T, Harusawa, S, Araki, L, Zuiderveld, OP, Smit, MJ, Imazu, T, Takashima, S, Yamamoto, Y, Sakamoto, Y, Kurihara, T, Leurs, R, Bakker, RA & Yamatodani, A 2003, 'A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine', Journal of Medicinal Chemistry, vol. 46, no. 14, pp. 3162-5. https://doi.org/10.1021/jm0300025

A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine. / Hashimoto, T.; Harusawa, S.; Araki, L.; Zuiderveld, O.P.; Smit, M.J.; Imazu, T.; Takashima, S.; Yamamoto, Y.; Sakamoto, Y.; Kurihara, T.; Leurs, R.; Bakker, R.A.; Yamatodani, A.

In: Journal of Medicinal Chemistry, Vol. 46, No. 14, 2003, p. 3162-5.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine

AU - Hashimoto, T.

AU - Harusawa, S.

AU - Araki, L.

AU - Zuiderveld, O.P.

AU - Smit, M.J.

AU - Imazu, T.

AU - Takashima, S.

AU - Yamamoto, Y.

AU - Sakamoto, Y.

AU - Kurihara, T.

AU - Leurs, R.

AU - Bakker, R.A.

AU - Yamatodani, A.

PY - 2003

Y1 - 2003

N2 - A series of 16 compounds related to chiral 4(5)-(5-aminomethyltetrahydrofuran-2-yl)imidazoles (1) have been designed, synthesized, and examined in vitro by radioligand displacement studies and functional assays for both the human H

AB - A series of 16 compounds related to chiral 4(5)-(5-aminomethyltetrahydrofuran-2-yl)imidazoles (1) have been designed, synthesized, and examined in vitro by radioligand displacement studies and functional assays for both the human H

U2 - 10.1021/jm0300025

DO - 10.1021/jm0300025

M3 - Article

VL - 46

SP - 3162

EP - 3165

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 14

ER -