A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine

T. Hashimoto, S. Harusawa, L. Araki, O.P. Zuiderveld, M.J. Smit, T. Imazu, S. Takashima, Y. Yamamoto, Y. Sakamoto, T. Kurihara, R. Leurs, R.A. Bakker, A. Yamatodani

Research output: Contribution to JournalArticleAcademicpeer-review


A series of 16 compounds related to chiral 4(5)-(5-aminomethyltetrahydrofuran-2-yl)imidazoles (1) have been designed, synthesized, and examined in vitro by radioligand displacement studies and functional assays for both the human H
Original languageEnglish
Pages (from-to)3162-5
JournalJournal of Medicinal Chemistry
Issue number14
Publication statusPublished - 2003


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