TY - JOUR
T1 - A structural insight into the reorientation of transmembrane domains 3 and 5 during family A GPCR activation
AU - Sansuk, K.
AU - Deupi, X.
AU - Torrecillas, I.
AU - Jongejan, A.
AU - Nijmeijer, S.
AU - Bakker, R.A.
AU - Pardo, L.
AU - Leurs, R.
PY - 2010
Y1 - 2010
N2 - Rearrangement of transmembrane domains (TMs) 3 and 5 after agonist binding is necessary for stabilization of the active state of class A G protein-coupled receptors (GPCRs). Using sitedirected mutagenesis and functional assays, we provide the first evidence that the TAS(I/V) sequence motif at positions 3.37 to 3.40, highly conserved in aminergic receptors, plays a key role in the activation of the histamine H
AB - Rearrangement of transmembrane domains (TMs) 3 and 5 after agonist binding is necessary for stabilization of the active state of class A G protein-coupled receptors (GPCRs). Using sitedirected mutagenesis and functional assays, we provide the first evidence that the TAS(I/V) sequence motif at positions 3.37 to 3.40, highly conserved in aminergic receptors, plays a key role in the activation of the histamine H
UR - https://www.scopus.com/pages/publications/78751487961
UR - https://www.scopus.com/inward/citedby.url?scp=78751487961&partnerID=8YFLogxK
U2 - 10.1124/mol.110.066068
DO - 10.1124/mol.110.066068
M3 - Article
SN - 0026-895X
JO - Molecular Pharmacology
JF - Molecular Pharmacology
ER -
