Abstract
Enoyl acyl carrier protein (ACP) reductase catalyses the last reductive step of fatty acid biosynthesis, reducing the enoyl group of a growing fatty acid chain attached to ACP to its acyl product using NAD(P)H as the cofactor. This enzyme is the target for the diazaborine class of anti-bacterial agents, the biocide triclosan, and one of the targets for the front-line anti-tuberculosis drug isoniazid. The structures of complexes of Escherichia coli enoyl-ACP reductase (ENR) from crystals grown in the presence of NAD
Original language | English |
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Pages (from-to) | 171-180 |
Journal | Journal of Molecular Biology |
Volume | 309 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2001 |