A sweet kiss with a bacterial touch: a potential positive feedback loop involved in shaping the oral microbiota

Remco Kort*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The human microbiota —the collection of microorganisms living on and inside the body—plays a fundamental role in human health. While diet, genetics, and environment strongly shape microbiota composition, social interactions may also influence the microbial communities associated with the human body. Intimate kissing is a widespread human behaviour that involves close contact and exchange of saliva, providing an opportunity for direct microbial transmission between individuals. This article explores the hypothesis that intimate kissing can induce a reinforcing cycle – a positive feedback loop - that shapes and stabilizes the oral microbiota of partners over time. Neurobiological pathways, including the gut microbiota–brain axis, might reinforce this feedback loop. Current evidence is synthesized and a study design outlined to explore how kissing may lead to sustained microbial sharing and potential systemic effects.

Original languageEnglish
Article number106777
Pages (from-to)1-12
Number of pages12
JournalEvolution and Human Behavior
Volume47
Issue number1
Early online date31 Oct 2025
DOIs
Publication statusPublished - Jan 2026

Bibliographical note

Publisher Copyright:
© 2025 The Author

Funding

The author gratefully acknowledges Gordon Getty and the Board of Directors of the Gruter Institute for Law and Behavioral Research for the invitation to present and discuss the hypothesis developed in this paper at the KissCon II conference in San Francisco, February 2025. Appreciation is also extended to the anonymous reviewer for providing valuable suggestions that substantially improved the manuscript.

FundersFunder number
Gordon Getty
Gruter Institute for Law

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