A technical note on challenge tests in human volunteers for multidimensional phenotyping

Daniel J. Vis; Margriet M.W.B. Hendriks; Manuela Sailer; Age K. Smilde; Hannelore Daniel; Johan A. Westerhuis

doi:10.1016/j.chemolab.2014.05.006

A technical note on challenge tests in human volunteers for multidimensional phenotyping

Daniel J. Vis
, Margriet M.W.B. Hendriks
, Manuela Sailer
, Age K. Smilde
, Hannelore Daniel
, Johan A. Westerhuis^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Challenge tests are used to reveal the adaptability and resilience of humans to get insight in their health. When contrasting challenge tests are used, various forms of adaptability can be tested and this gives a multidimensional view on the health of these individuals. Here we introduce a methodology to describe the similarities and differences on how individuals are positioned in the health space based on the responses to different challenge tests. Results show that anabolic and catabolic challenges differentiate healthy subjects in rather different ways. Considering these results we hypothesize that combining challenge tests can improve the understanding of the underlying multidimensional phenotype.

Original language	English
Pages (from-to)	81-84
Number of pages	4
Journal	Chemometrics and Intelligent Laboratory Systems
Volume	136
DOIs	https://doi.org/10.1016/j.chemolab.2014.05.006
Publication status	Published - 15 Aug 2014
Externally published	Yes

Funding

This project was carried out within the research program of the Netherlands Metabolomics Centre (NMC) which is part of the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research . Appendix A

Keywords

Challenge test
Metabolomics
Multidimensional phenotyping
Oral glucose tolerance test

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10.1016/j.chemolab.2014.05.006

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title = "A technical note on challenge tests in human volunteers for multidimensional phenotyping",

abstract = "Challenge tests are used to reveal the adaptability and resilience of humans to get insight in their health. When contrasting challenge tests are used, various forms of adaptability can be tested and this gives a multidimensional view on the health of these individuals. Here we introduce a methodology to describe the similarities and differences on how individuals are positioned in the health space based on the responses to different challenge tests. Results show that anabolic and catabolic challenges differentiate healthy subjects in rather different ways. Considering these results we hypothesize that combining challenge tests can improve the understanding of the underlying multidimensional phenotype.",

keywords = "Challenge test, Metabolomics, Multidimensional phenotyping, Oral glucose tolerance test",

author = "Vis, \{Daniel J.\} and Hendriks, \{Margriet M.W.B.\} and Manuela Sailer and Smilde, \{Age K.\} and Hannelore Daniel and Westerhuis, \{Johan A.\}",

year = "2014",

month = aug,

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doi = "10.1016/j.chemolab.2014.05.006",

language = "English",

volume = "136",

pages = "81--84",

journal = "Chemometrics and Intelligent Laboratory Systems",

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T1 - A technical note on challenge tests in human volunteers for multidimensional phenotyping

AU - Vis, Daniel J.

AU - Hendriks, Margriet M.W.B.

AU - Sailer, Manuela

AU - Smilde, Age K.

AU - Daniel, Hannelore

AU - Westerhuis, Johan A.

PY - 2014/8/15

Y1 - 2014/8/15

N2 - Challenge tests are used to reveal the adaptability and resilience of humans to get insight in their health. When contrasting challenge tests are used, various forms of adaptability can be tested and this gives a multidimensional view on the health of these individuals. Here we introduce a methodology to describe the similarities and differences on how individuals are positioned in the health space based on the responses to different challenge tests. Results show that anabolic and catabolic challenges differentiate healthy subjects in rather different ways. Considering these results we hypothesize that combining challenge tests can improve the understanding of the underlying multidimensional phenotype.

AB - Challenge tests are used to reveal the adaptability and resilience of humans to get insight in their health. When contrasting challenge tests are used, various forms of adaptability can be tested and this gives a multidimensional view on the health of these individuals. Here we introduce a methodology to describe the similarities and differences on how individuals are positioned in the health space based on the responses to different challenge tests. Results show that anabolic and catabolic challenges differentiate healthy subjects in rather different ways. Considering these results we hypothesize that combining challenge tests can improve the understanding of the underlying multidimensional phenotype.

KW - Challenge test

KW - Metabolomics

KW - Multidimensional phenotyping

KW - Oral glucose tolerance test

UR - https://www.scopus.com/pages/publications/84901999795

UR - https://www.scopus.com/pages/publications/84901999795#tab=citedBy

U2 - 10.1016/j.chemolab.2014.05.006

DO - 10.1016/j.chemolab.2014.05.006

M3 - Article

AN - SCOPUS:84901999795

SN - 0169-7439

VL - 136

SP - 81

EP - 84

JO - Chemometrics and Intelligent Laboratory Systems

JF - Chemometrics and Intelligent Laboratory Systems

ER -

A technical note on challenge tests in human volunteers for multidimensional phenotyping

Abstract

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Keywords

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