Absence of 5-HT3 and cholinergic mechanisms in improgan antinociception

J.B. Nalwalk, K. Svokos, R. Leurs, L.H. Hough

Research output: Contribution to JournalArticleAcademicpeer-review


Improgan, an analgesic derived from histamine antagonists, acts in the brain stem to activate descending non-opioid, pain-relieving circuits, but the mechanism of action of this drug remains elusive. Because improgan has a moderate affinity for 5-HT
Original languageEnglish
Pages (from-to)505-510
JournalPharmacology, Biochemistry and Behavior
Issue number3
Publication statusPublished - 2005


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