Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice.

S.T. van Cruchten, D.R. de Waart, C. Kunne, G.J. Hooiveld, M.V. Boekschoten, M.B. Katan, R.P. Elferink, R.F. Witkamp

Research output: Contribution to JournalArticle

Abstract

Cafestol is a diterpene present in unfiltered coffees. It is the most potent cholesterol-elevating compound present in the human diet. However, the precise mechanisms underlying this effect are still unclear. In contrast, cafestol is also known as a hepatoprotective compound, which is likely to be related to the induction of glutathione biosynthesis and conjugation. In the present study, we investigated whole-body distribution, biliary excretion, and portal bioavailability of cafestol in mice. First, dissection was used to study distribution. Five hours after an oral dose with
Original languageEnglish
Pages (from-to)635-40
JournalDrug Metabolism and Disposition
Volume38
Issue number4
DOIs
Publication statusPublished - 2010

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