Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice.

S.T. van Cruchten; D.R. de Waart; C. Kunne; G.J. Hooiveld; M.V. Boekschoten; M.B. Katan; R.P. Elferink; R.F. Witkamp

doi:10.1124/dmd.109.030213

Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice.

S.T. van Cruchten, D.R. de Waart, C. Kunne, G.J. Hooiveld, M.V. Boekschoten, M.B. Katan, R.P. Elferink, R.F. Witkamp

Nutrition and Health

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Cafestol is a diterpene present in unfiltered coffees. It is the most potent cholesterol-elevating compound present in the human diet. However, the precise mechanisms underlying this effect are still unclear. In contrast, cafestol is also known as a hepatoprotective compound, which is likely to be related to the induction of glutathione biosynthesis and conjugation. In the present study, we investigated whole-body distribution, biliary excretion, and portal bioavailability of cafestol in mice. First, dissection was used to study distribution. Five hours after an oral dose with

Original language	English
Pages (from-to)	635-40
Journal	Drug Metabolism and Disposition
Volume	38
Issue number	4
DOIs	https://doi.org/10.1124/dmd.109.030213
Publication status	Published - 2010

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10.1124/dmd.109.030213

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title = "Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice.",

abstract = "Cafestol is a diterpene present in unfiltered coffees. It is the most potent cholesterol-elevating compound present in the human diet. However, the precise mechanisms underlying this effect are still unclear. In contrast, cafestol is also known as a hepatoprotective compound, which is likely to be related to the induction of glutathione biosynthesis and conjugation. In the present study, we investigated whole-body distribution, biliary excretion, and portal bioavailability of cafestol in mice. First, dissection was used to study distribution. Five hours after an oral dose with",

author = "{van Cruchten}, S.T. and {de Waart}, D.R. and C. Kunne and G.J. Hooiveld and M.V. Boekschoten and M.B. Katan and R.P. Elferink and R.F. Witkamp",

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T1 - Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice.

AU - van Cruchten, S.T.

AU - de Waart, D.R.

AU - Kunne, C.

AU - Hooiveld, G.J.

AU - Boekschoten, M.V.

AU - Katan, M.B.

AU - Elferink, R.P.

AU - Witkamp, R.F.

PY - 2010

Y1 - 2010

N2 - Cafestol is a diterpene present in unfiltered coffees. It is the most potent cholesterol-elevating compound present in the human diet. However, the precise mechanisms underlying this effect are still unclear. In contrast, cafestol is also known as a hepatoprotective compound, which is likely to be related to the induction of glutathione biosynthesis and conjugation. In the present study, we investigated whole-body distribution, biliary excretion, and portal bioavailability of cafestol in mice. First, dissection was used to study distribution. Five hours after an oral dose with

AB - Cafestol is a diterpene present in unfiltered coffees. It is the most potent cholesterol-elevating compound present in the human diet. However, the precise mechanisms underlying this effect are still unclear. In contrast, cafestol is also known as a hepatoprotective compound, which is likely to be related to the induction of glutathione biosynthesis and conjugation. In the present study, we investigated whole-body distribution, biliary excretion, and portal bioavailability of cafestol in mice. First, dissection was used to study distribution. Five hours after an oral dose with

U2 - 10.1124/dmd.109.030213

DO - 10.1124/dmd.109.030213

M3 - Article

SN - 0090-9556

VL - 38

SP - 635

EP - 640

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

IS - 4

ER -

Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice.

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