TY - JOUR
T1 - Accumulation of adverse childhood events and overweight in children
T2 - A systematic review and meta-analysis
AU - Elsenburg, Leonie K.
AU - van Wijk, Kim J.E.
AU - Liefbroer, Aart C.
AU - Smidt, Nynke
PY - 2017/5
Y1 - 2017/5
N2 - Objective: This study systematically summarizes the evidence of all observational studies investigating the relation between accumulation of adverse life events and measures of overweight in children <18 years. Methods: MEDLINE, Embase, PsycINFO, and CINAHL were systematically searched (last search date 18 February 2015). The Newcastle-Ottawa Scale was used for methodological quality assessment. Study estimates were pooled using a random-effects model, and sources of heterogeneity were explored (PROSPERO registration number CRD42014014927). Results: Eighteen articles were included, containing five longitudinal (n = 6,361) and fourteen cross-sectional and case-control study results (n = 52,318). The pooled estimate of the longitudinal studies showed that accumulation of adverse life events is positively related to childhood overweight measures (OR [95% CI] = 1.12 [1.01-1.25]). Cross-sectional and case-control study results were heterogeneous. Subgroup analyses showed that cross-sectional and case-control studies using a continuous adverse events measure, studies using a continuous overweight measure, and studies in children >6-12 years also generated positive pooled estimates, while the pooled estimate of studies assessing recent adverse events (past 2 years) was indicative of no relation with overweight. Conclusions: Accumulation of adverse life events and childhood overweight measures are positively associated. However, increases in overweight measures in response to adverse childhood events do not seem to occur instantaneously.
AB - Objective: This study systematically summarizes the evidence of all observational studies investigating the relation between accumulation of adverse life events and measures of overweight in children <18 years. Methods: MEDLINE, Embase, PsycINFO, and CINAHL were systematically searched (last search date 18 February 2015). The Newcastle-Ottawa Scale was used for methodological quality assessment. Study estimates were pooled using a random-effects model, and sources of heterogeneity were explored (PROSPERO registration number CRD42014014927). Results: Eighteen articles were included, containing five longitudinal (n = 6,361) and fourteen cross-sectional and case-control study results (n = 52,318). The pooled estimate of the longitudinal studies showed that accumulation of adverse life events is positively related to childhood overweight measures (OR [95% CI] = 1.12 [1.01-1.25]). Cross-sectional and case-control study results were heterogeneous. Subgroup analyses showed that cross-sectional and case-control studies using a continuous adverse events measure, studies using a continuous overweight measure, and studies in children >6-12 years also generated positive pooled estimates, while the pooled estimate of studies assessing recent adverse events (past 2 years) was indicative of no relation with overweight. Conclusions: Accumulation of adverse life events and childhood overweight measures are positively associated. However, increases in overweight measures in response to adverse childhood events do not seem to occur instantaneously.
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U2 - 10.1002/oby.21797
DO - 10.1002/oby.21797
M3 - Review article
C2 - 28371524
AN - SCOPUS:85017424369
SN - 1930-7381
VL - 25
SP - 820
EP - 832
JO - Obesity
JF - Obesity
IS - 5
ER -