Abstract
The attenuation coefficient (AC) is a property related to the microstructure of tissue on a wavelength scale that can be estimated from optical coherence tomography (OCT) data. Since the OCT signal sensitivity is affected by the finite spectrometer/detector resolution called roll-off and the shape of the focused beam in the sample arm, ignoring these effects leads to severely biased estimates of AC. Previously, the signal intensity dependence on these factors has been modeled. In this paper, we study the dependence of the estimated AC on the beam-shape and focus depth experimentally. A method is presented to estimate the axial point spread function model parameters by fitting the OCT signal model for single scattered light to the averaged A-lines of multiple B-scans obtained from a homogeneous single-layer phantom. The estimated model parameters were used to compensate the signal for the axial point spread function and roll-off in order to obtain an accurate estimate of AC. The result shows a significant improvement in the accuracy of the estimation of AC after correcting for the shape of the OCT beam.
Original language | English |
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Title of host publication | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII |
Editors | Joseph A. Izatt, James G. Fujimoto, Valery V. Tuchin |
Publisher | SPIE |
ISBN (Electronic) | 9781510614512 |
DOIs | |
Publication status | Published - 2018 |
Event | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018 - San Francisco, United States Duration: 29 Jan 2018 → 31 Jan 2018 |
Publication series
Name | Proceedings |
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Publisher | SPIE |
Volume | 10483 |
Conference
Conference | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018 |
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Country/Territory | United States |
City | San Francisco |
Period | 29/01/18 → 31/01/18 |
Funding
This research was partially funded by the Netherlands Organization for Health Research and Development (ZonMw) TOP grant (91212061). We would like to acknowledge Dr. Dirk H. J. Poot1 for his technical support in this work.
Keywords
- attenuation coefficient
- beam-shape
- Cramér-Rao lower bound
- focus
- OCT
- point spread function
- Rayleigh length