Acetylcholine binding protein (AChBP): A secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels

T.K. Sixma, A.B. Smit

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Acetylcholine binding protein (AChBP) has recently been identified from molluskan glial cells. Glial cells secrete it into cholinergic synapses, where it plays a role in modulating synaptic transmission. This novel mechanism resembles glia-dependent modulation of glutamate synapses, with several key differences. AChBP is a homolog of the ligand binding domain of the pentameric ligand-gated ion-channels. The crystal structure of AChBP provides the first high-resolution structure for this family of Cys-loop receptors. Nicotinic acetylcholine receptors and related ion-channels such as GABA
Original languageEnglish
Pages (from-to)311-334
Number of pages28
JournalAnnual Review of Biophysics and Biomolecular Structure
Volume32
DOIs
Publication statusPublished - 2003

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