Acoustic force spectroscopy

G. Sitters, D. Kamsma, G. Thalhammer, M. Ritsch-Marte, E.J.G. Peterman, G.J.L. Wuite

Research output: Contribution to JournalArticleAcademicpeer-review


Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.
Original languageEnglish
Pages (from-to)47-50
JournalNature Methods
Issue number1
Publication statusPublished - 2015


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