Acoustic force spectroscopy

G. Sitters; D. Kamsma; G. Thalhammer; M. Ritsch-Marte; E.J.G. Peterman; G.J.L. Wuite

doi:10.1038/nmeth.3183

Acoustic force spectroscopy

G. Sitters, D. Kamsma, G. Thalhammer, M. Ritsch-Marte, E.J.G. Peterman, G.J.L. Wuite

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.

Original language	English
Pages (from-to)	47-50
Journal	Nature Methods
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/nmeth.3183
Publication status	Published - 2015

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title = "Acoustic force spectroscopy",

abstract = "Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.",

author = "G. Sitters and D. Kamsma and G. Thalhammer and M. Ritsch-Marte and E.J.G. Peterman and G.J.L. Wuite",

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AU - Sitters, G.

AU - Kamsma, D.

AU - Thalhammer, G.

AU - Ritsch-Marte, M.

AU - Peterman, E.J.G.

AU - Wuite, G.J.L.

PY - 2015

Y1 - 2015

N2 - Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.

AB - Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.

U2 - 10.1038/nmeth.3183

DO - 10.1038/nmeth.3183

M3 - Article

SN - 1548-7091

VL - 12

SP - 47

EP - 50

JO - Nature Methods

JF - Nature Methods

IS - 1

ER -

Acoustic force spectroscopy

Abstract

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