Actin Filament Length Tunes Elasticity of Flexibly Cross-Linked Actin Networks

K. E. Kasza; C.P. Broedersz; G.H. Koenderink; Y.C. Lin; W. Messner; F. Nakamura; T. P. Stossel; F.C. Mac Kintosh; D. A. Weitz

doi:10.1016/j.bpj.2010.06.025

Actin Filament Length Tunes Elasticity of Flexibly Cross-Linked Actin Networks

K. E. Kasza, C.P. Broedersz, G.H. Koenderink, Y.C. Lin, W. Messner, F. Nakamura, T. P. Stossel, F.C. Mac Kintosh, D. A. Weitz

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers. © 2010 by the Biophysical Society.

Original language	English
Pages (from-to)	1091-1100
Journal	Biophysical Journal
Volume	99
Issue number	4
DOIs	https://doi.org/10.1016/j.bpj.2010.06.025
Publication status	Published - 2010

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title = "Actin Filament Length Tunes Elasticity of Flexibly Cross-Linked Actin Networks",

abstract = "Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers. {\textcopyright} 2010 by the Biophysical Society.",

author = "Kasza, {K. E.} and C.P. Broedersz and G.H. Koenderink and Y.C. Lin and W. Messner and F. Nakamura and Stossel, {T. P.} and {Mac Kintosh}, F.C. and Weitz, {D. A.}",

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doi = "10.1016/j.bpj.2010.06.025",

language = "English",

volume = "99",

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T1 - Actin Filament Length Tunes Elasticity of Flexibly Cross-Linked Actin Networks

AU - Kasza, K. E.

AU - Broedersz, C.P.

AU - Koenderink, G.H.

AU - Lin, Y.C.

AU - Messner, W.

AU - Nakamura, F.

AU - Stossel, T. P.

AU - Mac Kintosh, F.C.

AU - Weitz, D. A.

PY - 2010

Y1 - 2010

N2 - Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers. © 2010 by the Biophysical Society.

AB - Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers. © 2010 by the Biophysical Society.

U2 - 10.1016/j.bpj.2010.06.025

DO - 10.1016/j.bpj.2010.06.025

M3 - Article

SN - 0006-3495

VL - 99

SP - 1091

EP - 1100

JO - Biophysical Journal

JF - Biophysical Journal

IS - 4

ER -

Actin Filament Length Tunes Elasticity of Flexibly Cross-Linked Actin Networks

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