Actin Filament Length Tunes Elasticity of Flexibly Cross-Linked Actin Networks

K. E. Kasza, C.P. Broedersz, G.H. Koenderink, Y.C. Lin, W. Messner, F. Nakamura, T. P. Stossel, F.C. Mac Kintosh, D. A. Weitz

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers. © 2010 by the Biophysical Society.
Original languageEnglish
Pages (from-to)1091-1100
JournalBiophysical Journal
Volume99
Issue number4
DOIs
Publication statusPublished - 2010

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