Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers. © 2010 by the Biophysical Society.
Kasza, K. E., Broedersz, C. P., Koenderink, G. H., Lin, Y. C., Messner, W., Nakamura, F., ... Weitz, D. A. (2010). Actin Filament Length Tunes Elasticity of Flexibly Cross-Linked Actin Networks. Biophysical Journal, 99(4), 1091-1100. https://doi.org/10.1016/j.bpj.2010.06.025