Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for low concentration of organophosphate insecticides

M. Meijer; T. Hamers; R.H.S. Westerink

doi:10.1016/j.neuro.2014.01.008

Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for low concentration of organophosphate insecticides

M. Meijer, T. Hamers, R.H.S. Westerink

Chemistry and Biology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Organophosphates (OPs) and carbamates are widely used insecticides that exert their neurotoxicity via inhibition of acetylcholine esterase (AChE) and subsequent overexcitation. OPs can induce additional neurotoxic effects at concentrations below those for inhibition of AChE, indicating other mechanisms of action are also involved. Since tight regulation of the intracellular calcium concentration ([Ca

Original language	English
Pages (from-to)	110-116
Journal	Neurotoxicology
Volume	43
DOIs	https://doi.org/10.1016/j.neuro.2014.01.008
Publication status	Published - 2014

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10.1016/j.neuro.2014.01.008

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title = "Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for low concentration of organophosphate insecticides",

abstract = "Organophosphates (OPs) and carbamates are widely used insecticides that exert their neurotoxicity via inhibition of acetylcholine esterase (AChE) and subsequent overexcitation. OPs can induce additional neurotoxic effects at concentrations below those for inhibition of AChE, indicating other mechanisms of action are also involved. Since tight regulation of the intracellular calcium concentration ([Ca",

author = "M. Meijer and T. Hamers and R.H.S. Westerink",

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AU - Meijer, M.

AU - Hamers, T.

AU - Westerink, R.H.S.

PY - 2014

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AB - Organophosphates (OPs) and carbamates are widely used insecticides that exert their neurotoxicity via inhibition of acetylcholine esterase (AChE) and subsequent overexcitation. OPs can induce additional neurotoxic effects at concentrations below those for inhibition of AChE, indicating other mechanisms of action are also involved. Since tight regulation of the intracellular calcium concentration ([Ca

U2 - 10.1016/j.neuro.2014.01.008

DO - 10.1016/j.neuro.2014.01.008

M3 - Article

SN - 0161-813X

VL - 43

SP - 110

EP - 116

JO - Neurotoxicology

JF - Neurotoxicology

ER -

Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for low concentration of organophosphate insecticides

Abstract

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