Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for low concentration of organophosphate insecticides

M. Meijer, T. Hamers, R.H.S. Westerink

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Organophosphates (OPs) and carbamates are widely used insecticides that exert their neurotoxicity via inhibition of acetylcholine esterase (AChE) and subsequent overexcitation. OPs can induce additional neurotoxic effects at concentrations below those for inhibition of AChE, indicating other mechanisms of action are also involved. Since tight regulation of the intracellular calcium concentration ([Ca
Original languageEnglish
Pages (from-to)110-116
JournalNeurotoxicology
Volume43
DOIs
Publication statusPublished - 2014

Fingerprint Dive into the research topics of 'Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for low concentration of organophosphate insecticides'. Together they form a unique fingerprint.

  • Cite this